{"id":"W4213431883","doi":"10.1101/2022.02.23.481568","title":"Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Michael Smith Health Research BC; National Science Foundation","keywords":"Allosteric regulation; Phospholipase C; Receptor tyrosine kinase; Biochemistry; Receptor; Chemistry; Cell biology; Isozyme; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005002794,0.0003499567,0.0004017531,0.000158433,0.00009333769,0.00003121835,0.0009429217,0.000321893,0.0001016415],"category_scores_gemma":[0.0002389268,0.0003246804,0.0002311062,0.0004565409,0.000111949,0.0000059218,0.002124792,0.0003539601,0.000003641043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047783,"about_ca_system_score_gemma":0.0005129136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001021043,"about_ca_topic_score_gemma":0.0000191856,"domain_scores_codex":[0.9975618,0.0002580076,0.0005429259,0.0007147531,0.000568343,0.0003541419],"domain_scores_gemma":[0.9972166,0.00002688417,0.000467623,0.001770722,0.0003841557,0.0001339955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169107,0.000113052,0.005182128,0.0005779896,0.0001346096,0.000001641726,0.00001100903,0.0010306,0.9924347,0.0001773449,0.000164656,0.000003132853],"study_design_scores_gemma":[0.0002577446,0.000190355,0.06115003,0.0001536424,0.0000425401,1.516293e-8,0.000006537611,0.0002491092,0.9343308,0.000002190061,0.003318771,0.0002982617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996176,0.0005869099,0.0002155957,0.0003507516,0.0005200774,0.001495317,0.0006187151,0.00002396552,0.00001268345],"genre_scores_gemma":[0.9982206,0.0001342579,0.00103471,0.00006022976,0.00009746397,0.0003221128,0.00000484061,0.00009117658,0.00003456413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05810393,"threshold_uncertainty_score":0.9999205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196934410227616,"score_gpt":0.2588981905637572,"score_spread":0.2369288464614811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}