{"id":"W4213432446","doi":"10.21203/rs.3.rs-1375001/v1","title":"Phb1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Prohibitin; Mitochondrion; Ovarian cancer; Western blot; Apoptosis; Biology; Immunoprecipitation; Cisplatin; Proximity ligation assay; Inner mitochondrial membrane; Molecular biology; Cytosol; Fragmentation (computing); Cancer research; Cell culture; Cell biology; Cancer; Biochemistry; Receptor; Genetics; Chemotherapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008629738,0.0001856473,0.000123297,0.0001714746,0.0001737516,0.0002354604,0.0001029318,0.0002251502,0.001465893],"category_scores_gemma":[0.00008427195,0.0001027098,0.0001298526,0.0001049203,0.0001625218,0.0001501034,0.0001663445,0.0003406703,0.0002560445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298538,"about_ca_system_score_gemma":0.000101082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003858263,"about_ca_topic_score_gemma":0.0005440097,"domain_scores_codex":[0.9999218,0.0000100162,0.000005197932,0.00002073859,0.00002187781,0.00002022379],"domain_scores_gemma":[0.9999366,0.000005781575,0.00002487079,0.000004101553,0.000007097711,0.00002144677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001795578,0.00001925601,0.001778666,0.00005757793,0.000006659062,0.00006697891,0.00001943645,0.00004183882,0.9969425,0.00005535183,0.00004565287,0.0007865465],"study_design_scores_gemma":[0.00004372716,0.0003918046,0.1217694,0.00002595262,0.00003908602,0.001324911,0.000144007,0.00178281,0.8703935,0.0001194962,0.00395857,0.000006712778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966271,0.001939551,0.0005867669,0.0001017735,0.000008151623,0.000009770675,0.0002102251,0.00002150101,0.0004952378],"genre_scores_gemma":[0.9984782,0.0004387339,0.0002170173,0.00002588634,0.000002527669,0.00001144636,0.0002181729,0.000002484573,0.0006056523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465893,"threshold_uncertainty_score":0.004903853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624714648454465,"score_gpt":0.3375588100036052,"score_spread":0.3113116635190606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}