{"id":"W4213439607","doi":"10.1371/journal.pbio.3001427","title":"LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; National Cancer Institute; National Institutes of Health; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; Merck KGaA; Merck Sharp and Dohme; Ontario Ministry of Economic Development and Innovation; Genome Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"Allosteric regulation; Protein kinase domain; LRRK2; Helix (gastropod); Kinase; Biology; Biophysics; Crosstalk; Hydrogen–deuterium exchange; Leucine-rich repeat; Biochemistry; Cell biology; Chemistry; Physics; Enzyme; Mutation; Hydrogen; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008595507,0.0002236871,0.0001718641,0.000136106,0.0001796281,0.0001701253,0.0001904013,0.0001447453,0.0008631163],"category_scores_gemma":[0.0001176792,0.0001016353,0.0001475561,0.0001150399,0.0001618093,0.0002011464,0.0001483239,0.0001745981,0.0000706161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162701,"about_ca_system_score_gemma":0.0002562843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001895756,"about_ca_topic_score_gemma":0.002154215,"domain_scores_codex":[0.9999744,0.000003246681,0.000001020192,0.000008419418,0.00000644823,0.000006442052],"domain_scores_gemma":[0.999975,0.000006371262,0.000005640686,0.000002768193,0.000003732492,0.000006553365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004982979,0.000187877,0.01470469,0.0001610839,0.00011427,0.0004326926,0.0001849772,0.2694855,0.6929547,0.007169266,0.0009976286,0.01310905],"study_design_scores_gemma":[0.00003033864,0.00006196818,0.009580961,0.000003905469,0.00001614956,0.00006151386,0.0000334722,0.9497101,0.03882182,0.000951647,0.0007148146,0.00001324795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939924,0.00006471862,0.004329864,0.00005086265,0.000003365131,0.000004979463,0.0001008692,0.000111695,0.001341379],"genre_scores_gemma":[0.998432,0.00005053026,0.001265706,0.000007005466,9.686763e-7,0.000006207221,0.0001067078,0.00001111963,0.0001197169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001895756,"threshold_uncertainty_score":0.003769517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009774028089432108,"score_gpt":0.2249716374577179,"score_spread":0.2151976093682858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}