{"id":"W4213439607","doi":"10.1371/journal.pbio.3001427","title":"LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; National Cancer Institute; National Institutes of Health; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; Merck KGaA; Merck Sharp and Dohme; Ontario Ministry of Economic Development and Innovation; Genome Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"Allosteric regulation; Protein kinase domain; LRRK2; Helix (gastropod); Kinase; Biology; Biophysics; Crosstalk; Hydrogen–deuterium exchange; Leucine-rich repeat; Biochemistry; Cell biology; Chemistry; Physics; Enzyme; Mutation; Hydrogen; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141788,0.0001694911,0.0003336625,0.00006261827,0.000235218,0.00001175654,0.0006373456,0.0001491791,0.0000723402],"category_scores_gemma":[0.0001307493,0.0001299176,0.0003016589,0.0003607315,0.0002124638,0.000002283055,0.0004680531,0.000134573,0.000003387468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003360704,"about_ca_system_score_gemma":0.00006145479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002458794,"about_ca_topic_score_gemma":0.00005584838,"domain_scores_codex":[0.9986973,0.0002001593,0.0003054822,0.0003904074,0.0001327502,0.0002739257],"domain_scores_gemma":[0.9990917,0.00006888262,0.0002290248,0.0005021558,0.00005955805,0.00004870672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007901794,0.00008195588,0.07232777,0.00002274623,0.001418296,0.000002017737,0.0000217127,0.00005887134,0.9257488,0.00003350566,0.00009600494,0.0001093637],"study_design_scores_gemma":[0.0004665112,0.00018813,0.01641999,0.000004357667,0.00109067,0.00001741553,0.0001356396,0.0005030078,0.978452,0.00006754725,0.002391245,0.0002635363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954435,0.0003886936,0.0002147708,0.0003379585,0.00008970487,0.0001666456,0.002988991,0.00001037,0.0003594085],"genre_scores_gemma":[0.997659,0.00002605291,0.00001333594,0.0001611413,0.00008827072,0.00003429257,0.001272931,0.00001103763,0.0007339102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05590778,"threshold_uncertainty_score":0.5297886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009774028089432108,"score_gpt":0.2249716374577179,"score_spread":0.2151976093682858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}