{"id":"W4213441139","doi":"10.1136/bmjno-2021-000215","title":"Effect of fingolimod on health-related quality of life in paediatric patients with multiple sclerosis: results from the phase 3 PARADIG<i>MS</i> Study","year":2022,"lang":"en","type":"article","venue":"BMJ Neurology Open","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Servier; Eisai; Race to Erase MS; Lourie Foundation; Genentech; Multiple Sclerosis Society; F. Hoffmann-La Roche; Teva Pharmaceutical Industries; Verily Life Sciences; Patient-Centered Outcomes Research Institute; Biogen; U.S. Department of Defense; Sanofi; National Multiple Sclerosis Society","keywords":"Fingolimod; Medicine; Multiple sclerosis; Quality of life (healthcare); Post-hoc analysis; Adverse effect; Psychosocial; Internal medicine; Post hoc; Expanded Disability Status Scale; Physical therapy; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003544553,0.0004268959,0.001328026,0.0002154706,0.0001692261,0.0004956203,0.000335206,0.0004407165,0.0006533857],"category_scores_gemma":[0.002409821,0.0001627704,0.001754921,0.0004423835,0.0004495543,0.0002984497,0.0003815339,0.001047846,0.0000943562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004648033,"about_ca_system_score_gemma":0.000721657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008755848,"about_ca_topic_score_gemma":0.000989172,"domain_scores_codex":[0.9984462,0.001051901,0.0001211299,0.0001017551,0.0001712177,0.0001077726],"domain_scores_gemma":[0.997758,0.0006266423,0.001041395,0.0001019043,0.0001222615,0.0003498902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4213641,0.01205536,0.3278889,0.002944079,0.01024489,0.0006720935,0.0007462875,0.00223037,0.01148937,0.0002454928,0.002475752,0.2076434],"study_design_scores_gemma":[0.06614154,0.1960908,0.7251019,0.0003114405,0.004087268,0.0007939665,0.0001965441,0.0007316665,0.002623431,0.000139043,0.003738272,0.00004399861],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905655,0.008079518,0.0001343355,0.000166593,0.00002415278,0.0001627597,0.0005290303,0.000006820822,0.0003312403],"genre_scores_gemma":[0.9936162,0.004339552,0.0006654226,0.0002090323,0.00007089624,0.0002558861,0.0007368993,0.00000499185,0.0001009974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003544553,"threshold_uncertainty_score":0.0187456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1104055665620109,"score_gpt":0.3882487616690394,"score_spread":0.2778431951070285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}