{"id":"W4213441139","doi":"10.1136/bmjno-2021-000215","title":"Effect of fingolimod on health-related quality of life in paediatric patients with multiple sclerosis: results from the phase 3 PARADIG<i>MS</i> Study","year":2022,"lang":"en","type":"article","venue":"BMJ Neurology Open","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Servier; Eisai; Race to Erase MS; Lourie Foundation; Genentech; Multiple Sclerosis Society; F. Hoffmann-La Roche; Teva Pharmaceutical Industries; Verily Life Sciences; Patient-Centered Outcomes Research Institute; Biogen; U.S. Department of Defense; Sanofi; National Multiple Sclerosis Society","keywords":"Fingolimod; Medicine; Multiple sclerosis; Quality of life (healthcare); Post-hoc analysis; Adverse effect; Psychosocial; Internal medicine; Post hoc; Expanded Disability Status Scale; Physical therapy; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005327956,0.0002402052,0.001289452,0.000175727,0.000241057,0.000009955829,0.0007081426,0.00005852758,0.00004111683],"category_scores_gemma":[0.007035504,0.000152825,0.00009081207,0.0007554468,0.0001984412,0.00005941707,0.001049583,0.0008276124,0.00000379798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005520707,"about_ca_system_score_gemma":0.0002288736,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01764925,"about_ca_topic_score_gemma":0.001625757,"domain_scores_codex":[0.9900585,0.006597518,0.00140388,0.000647095,0.0008735995,0.0004194198],"domain_scores_gemma":[0.9910891,0.006815894,0.000876893,0.0009768817,0.00009926483,0.000141936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09799509,0.004174402,0.8891509,0.00005148435,0.000206088,0.00001192086,0.002395862,0.001184054,0.00006411094,0.000001419001,0.002239133,0.002525557],"study_design_scores_gemma":[0.07927007,0.03353562,0.8863844,0.00004098406,0.0000403187,4.712529e-7,0.000168789,0.0003522153,0.00003855573,0.000003961812,0.00006572378,0.00009887574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838369,0.0001293412,2.949292e-7,0.00473005,0.00009728671,0.01008572,0.0009869148,0.00001900654,0.0001144444],"genre_scores_gemma":[0.9974449,0.00003354999,0.00001486846,0.001243356,0.00002531616,0.001023691,0.0001792131,0.00002917673,0.000005948854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02936122,"threshold_uncertainty_score":0.9888923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1104055665620109,"score_gpt":0.3882487616690394,"score_spread":0.2778431951070285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}