{"id":"W4213446588","doi":"10.1016/j.reprotox.2022.02.004","title":"Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro","year":2022,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Kungl. Skogs- och Lantbruksakademien; Vetenskapsrådet; Carl Tryggers Stiftelse för Vetenskaplig Forskning; Science for Life Laboratory; Svenska Forskningsrådet Formas","keywords":"Oocyte; Blastocyst; Biology; Andrology; DNA methylation; Embryo; In vitro maturation; Transcriptome; Embryogenesis; Embryo culture; Cell biology; Molecular biology; Genetics; Gene; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001826259,0.0001992117,0.0003385647,0.0002830033,0.0002113646,0.00001904909,0.0002919668,0.0000924991,0.001046704],"category_scores_gemma":[0.0002672125,0.0002102499,0.00002849702,0.0008471746,0.0001751752,0.0002085134,0.0003786224,0.0005611961,0.00002560548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006613428,"about_ca_system_score_gemma":0.00003300017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007727456,"about_ca_topic_score_gemma":0.004001123,"domain_scores_codex":[0.9968766,0.0007528504,0.0003257651,0.001078065,0.0003674449,0.0005992523],"domain_scores_gemma":[0.9992865,0.000130852,0.00008468737,0.0003721237,0.00001391675,0.0001119303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001650447,0.0001387221,0.006589297,0.000008904394,0.000007334366,0.00003026573,0.006947211,0.0009962129,0.8825669,0.00001666566,0.0000952561,0.1009528],"study_design_scores_gemma":[0.001435161,0.001049548,0.4893526,0.000008228246,0.00000841263,0.00003556917,0.00222038,0.0003541136,0.489558,0.0003657737,0.01520139,0.0004108351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897805,0.002939162,0.00001139768,0.005096769,0.0002015972,0.0007571097,0.00004123741,0.00002899495,0.001143246],"genre_scores_gemma":[0.9977825,0.0001155406,0.0004704077,0.0002954386,0.0001039432,0.0003112105,0.00001930614,0.00002234872,0.0008793205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4827633,"threshold_uncertainty_score":0.9998665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02447343426559253,"score_gpt":0.2742464181198083,"score_spread":0.2497729838542157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}