{"id":"W4213446588","doi":"10.1016/j.reprotox.2022.02.004","title":"Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro","year":2022,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Kungl. Skogs- och Lantbruksakademien; Vetenskapsrådet; Carl Tryggers Stiftelse för Vetenskaplig Forskning; Science for Life Laboratory; Svenska Forskningsrådet Formas","keywords":"Oocyte; Blastocyst; Biology; Andrology; DNA methylation; Embryo; In vitro maturation; Transcriptome; Embryogenesis; Embryo culture; Cell biology; Molecular biology; Genetics; Gene; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272639,0.000196016,0.0001795656,0.0001180324,0.0001392288,0.0002297626,0.00009303106,0.000210562,0.001145139],"category_scores_gemma":[0.0001818462,0.00009870349,0.0001818358,0.00009346009,0.0001482427,0.0001056183,0.000143251,0.0002104486,0.0001641239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518924,"about_ca_system_score_gemma":0.000192185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002662613,"about_ca_topic_score_gemma":0.004176776,"domain_scores_codex":[0.9998736,0.00002233778,0.000008973493,0.0000305661,0.0000403581,0.00002412914],"domain_scores_gemma":[0.9999185,0.00001858617,0.00002806107,0.000006298144,0.00001789868,0.00001074117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004187707,0.000002500943,0.0004564503,0.0000284746,0.000003645583,0.00002652133,0.00001468007,0.0000249196,0.9988157,0.00001190554,0.000014365,0.0005590121],"study_design_scores_gemma":[0.000005610828,0.0002813094,0.04599485,0.00001440115,0.00003050012,0.0001954227,0.0001273667,0.0002482187,0.9493882,0.00005859857,0.003647735,0.0000077818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885315,0.004762685,0.003561595,0.0001707218,0.00004205944,0.00003625308,0.0007922219,0.00003904886,0.002063882],"genre_scores_gemma":[0.992634,0.002219352,0.001576042,0.0001153201,0.00001326353,0.00003877199,0.0006007408,0.00001612463,0.002786333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002662613,"threshold_uncertainty_score":0.005294204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02447343426559253,"score_gpt":0.2742464181198083,"score_spread":0.2497729838542157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}