{"id":"W4213448720","doi":"10.21203/rs.3.rs-1336103/v1","title":"Lung muscarinic receptor occupancy by tiotropium: translational PET studies in non-human primates and humans","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"Karolinska Institutet","keywords":"Occupancy; Muscarinic acetylcholine receptor; Lung; Medicine; Neuroscience; Receptor; Internal medicine; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004755492,0.0003871542,0.0003766781,0.0002099956,0.0002987649,0.0003310813,0.0002125557,0.0004625714,0.002042988],"category_scores_gemma":[0.0003322379,0.0002116677,0.0001970317,0.0001802542,0.0006975307,0.0002976714,0.0001847551,0.0003901207,0.0005036982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844775,"about_ca_system_score_gemma":0.0002392631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001735245,"about_ca_topic_score_gemma":0.001968857,"domain_scores_codex":[0.9998139,0.00007429559,0.000006151088,0.00005967302,0.00002592586,0.00002000926],"domain_scores_gemma":[0.9998829,0.00002986205,0.00002844208,0.00002280465,0.00001628075,0.00001951802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006937859,0.00172209,0.03328445,0.0006283738,0.0001886706,0.002039912,0.0007191785,0.0008034234,0.9077344,0.00042908,0.0011759,0.04433653],"study_design_scores_gemma":[0.000788557,0.06910059,0.5526449,0.0001380855,0.0006491933,0.0243691,0.002411349,0.007383679,0.3168643,0.001406966,0.02416236,0.00008088419],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988552,0.004762198,0.004126539,0.0001329953,0.00002292763,0.0001649153,0.0002900581,0.00006731573,0.001881083],"genre_scores_gemma":[0.9936395,0.001800524,0.002085407,0.0001593076,0.00002839663,0.000202465,0.000438431,0.00001361588,0.001632268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002042988,"threshold_uncertainty_score":0.006834447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07095455989370654,"score_gpt":0.4613360662774247,"score_spread":0.3903815063837182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}