{"id":"W4213449879","doi":"10.1016/j.ijbiomac.2022.02.096","title":"Controlled release of 5-fluorouracil to melanoma cells using a hydrogel/micelle composites based on deoxycholic acid and carboxymethyl chitosan","year":2022,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Kermanshah University of Medical Sciences","keywords":"Chitosan; Dynamic light scattering; Drug delivery; Zeta potential; Chemistry; Self-healing hydrogels; Deoxycholic acid; Nanomedicine; Micelle; Nuclear chemistry; Fourier transform infrared spectroscopy; Materials science; Nanotechnology; Chemical engineering; Organic chemistry; Bile acid; Nanoparticle; Biochemistry; Aqueous solution","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005161714,0.0002005225,0.0004499418,0.0002689654,0.0001522875,0.00001544234,0.0005568403,0.0001022796,0.0004753533],"category_scores_gemma":[0.0001372578,0.0001638075,0.0002052884,0.0001271865,0.0001643639,0.00004634045,0.0001801997,0.00064303,0.000003154353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008599593,"about_ca_system_score_gemma":0.00006258151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000106654,"about_ca_topic_score_gemma":7.48609e-7,"domain_scores_codex":[0.9978129,0.000640158,0.0006743787,0.0002267258,0.0004162839,0.0002295593],"domain_scores_gemma":[0.9984158,0.0006588543,0.0004888696,0.00008974602,0.0001557304,0.0001909777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00811507,0.0006889026,0.001774876,0.0000064765,0.0003546031,0.0004204601,0.0001344737,0.05952447,0.9249848,0.0001910367,0.0000293808,0.003775518],"study_design_scores_gemma":[0.009232647,0.002197846,0.0005688295,0.00004225302,0.0001360247,0.0002827526,0.0001888214,0.03314347,0.951664,0.0003381904,0.001929929,0.0002752302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940302,0.0007118181,0.002805418,0.0007260311,0.0008388417,0.0002788192,0.000234856,0.0000114686,0.0003625582],"genre_scores_gemma":[0.9937884,0.0001096532,0.002756882,0.003175033,0.0001211914,0.00001491958,0.00001254367,0.00001333463,0.000007995322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02667927,"threshold_uncertainty_score":0.6679875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06625520198708804,"score_gpt":0.38904473531362,"score_spread":0.322789533326532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}