{"id":"W4213449879","doi":"10.1016/j.ijbiomac.2022.02.096","title":"Controlled release of 5-fluorouracil to melanoma cells using a hydrogel/micelle composites based on deoxycholic acid and carboxymethyl chitosan","year":2022,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Kermanshah University of Medical Sciences","keywords":"Chitosan; Dynamic light scattering; Drug delivery; Zeta potential; Chemistry; Self-healing hydrogels; Deoxycholic acid; Nanomedicine; Micelle; Nuclear chemistry; Fourier transform infrared spectroscopy; Materials science; Nanotechnology; Chemical engineering; Organic chemistry; Bile acid; Nanoparticle; Biochemistry; Aqueous solution","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410693,0.000270216,0.0001400519,0.0001562902,0.0001383973,0.0002109046,0.0001391592,0.0002716545,0.0006167305],"category_scores_gemma":[0.0001493994,0.000122921,0.0002478066,0.0001064833,0.0001518784,0.0002720438,0.0001201247,0.0003022455,0.0001325533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282965,"about_ca_system_score_gemma":0.0002578468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001623452,"about_ca_topic_score_gemma":0.00238699,"domain_scores_codex":[0.9999193,0.000008352721,0.000008842463,0.00002001865,0.00001884689,0.00002465096],"domain_scores_gemma":[0.9999021,0.00002383486,0.0000326115,0.000007666474,0.00001576087,0.00001790835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000453819,0.000008917208,0.00003915588,0.00002098601,0.00000216027,0.00002571323,0.00001020846,0.00006412661,0.9989969,0.00002918349,0.00001074618,0.0007465184],"study_design_scores_gemma":[0.000008010415,0.0001360832,0.0005414956,0.000002378518,0.000007691244,0.00003474446,0.00000540388,0.0004537941,0.9983552,0.000004465509,0.0004470787,0.000003532842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994314,0.001510674,0.002771176,0.00006225664,0.00003980429,0.00002480707,0.00008950415,0.00005985815,0.001128098],"genre_scores_gemma":[0.9970585,0.0003663877,0.001460802,0.0000201489,0.000007192628,0.00001267858,0.00004565658,0.00000809016,0.001020473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623452,"threshold_uncertainty_score":0.003228009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06625520198708804,"score_gpt":0.38904473531362,"score_spread":0.322789533326532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}