{"id":"W4213452411","doi":"10.33380/2305-2066-2022-11-1-140-147","title":"Pharmacokinetics Study of the Long-acting Antiarrhythmic Drug of Lappaconitine Hydrobromide (Allaforte®, JSC \"Pharmcenter VILAR\", Russia)","year":2022,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Plant-based Medicinal Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Pharmacokinetics; Cmax; Pharmacology; Drug; Plasma concentration; Alkaloid; Chemistry; Medicine; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781272,0.0001639645,0.0002275822,0.0001011108,0.00006349215,0.0001496773,0.0001013289,0.000128352,0.001244229],"category_scores_gemma":[0.0002895725,0.0001150833,0.000187405,0.00009912729,0.00009279946,0.0001273047,0.00006780897,0.0002766362,0.0002392426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149117,"about_ca_system_score_gemma":0.0002147511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005747221,"about_ca_topic_score_gemma":0.0005421343,"domain_scores_codex":[0.9998766,0.00003649889,0.000006992145,0.00003377711,0.00003160885,0.00001450251],"domain_scores_gemma":[0.999927,0.00001900595,0.00001945058,0.000008035261,0.00001165471,0.00001474466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007939968,0.0004717146,0.009855983,0.0003467531,0.0002367514,0.0002808786,0.0001460657,0.001925693,0.8882974,0.000374027,0.0009583629,0.0891664],"study_design_scores_gemma":[0.001310364,0.03986814,0.1992122,0.0000781017,0.0005255824,0.005807486,0.0001584855,0.02041918,0.6992712,0.0005390433,0.0327097,0.000100544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799812,0.008679801,0.007765489,0.0001554877,0.00004050472,0.00009432748,0.0005713435,0.0001507878,0.002560942],"genre_scores_gemma":[0.9935915,0.001861308,0.002451572,0.00007080873,0.00001488375,0.00004104095,0.0004230157,0.00001916603,0.001526679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244229,"threshold_uncertainty_score":0.004162312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08764112469374505,"score_gpt":0.4045696862444642,"score_spread":0.3169285615507191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}