{"id":"W4213456994","doi":"10.1101/2022.02.24.481751","title":"Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Vetenskapsrådet","keywords":"Cooperativity; Myosin; Actin; Molecular motor; Biophysics; Protein filament; Myosin head; Muscle contraction; Cooperative binding; Chemistry; Meromyosin; Motor protein; Binding site; Myosin light-chain kinase; Biochemistry; Biology; Cell biology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003925719,0.0001991753,0.000253799,0.0003324103,0.0002541886,0.0002942392,0.0005052877,0.0003200651,0.0007352799],"category_scores_gemma":[0.0006598771,0.0002510671,0.0002241175,0.0001585502,0.0002844954,0.0003457939,0.0001986723,0.0004178512,0.0001102881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304672,"about_ca_system_score_gemma":0.0001113085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007721496,"about_ca_topic_score_gemma":0.00053265,"domain_scores_codex":[0.9996339,0.00004207746,0.00001807046,0.00009068661,0.0001459324,0.00006918029],"domain_scores_gemma":[0.9993334,0.0002628296,0.0001599617,0.00005718316,0.000121509,0.00006501086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003987514,0.00002938457,0.001069097,0.00002290379,0.000008723543,0.00006099411,0.00004180071,0.0003681367,0.9970324,0.0001455665,0.00003134158,0.00114985],"study_design_scores_gemma":[0.00003035506,0.0003117195,0.07406215,0.00001178998,0.00004506555,0.0003200506,0.0001831014,0.06548717,0.8580828,0.0004427507,0.0009910578,0.00003192044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99363,0.0002282178,0.005558797,0.00003081134,0.000009936084,0.00001315147,0.00002565175,0.00003278006,0.0004705609],"genre_scores_gemma":[0.9971566,0.00008113708,0.002353379,0.00001863761,0.000005813902,0.00001602353,0.00002467269,0.000007315859,0.0003363643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007721496,"threshold_uncertainty_score":0.002459764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356605006447306,"score_gpt":0.2217619533868489,"score_spread":0.2081959033223758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}