{"id":"W4214492388","doi":"10.1093/nar/gkac138","title":"The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Sunnybrook Health Science Centre","funders":"Janssen Biotech; Canadian Institutes of Health Research; Genentech; Pfizer; Vetenskapsrådet; Linköpings Universitet; Barncancerfonden; Merck KGaA; Genome Canada; Bristol-Myers Squibb Canada; Cancerfonden; Bayer; Princess Margaret Cancer Foundation; Takeda Pharmaceuticals U.S.A.; National Supercomputer Centre, Linköpings Universitet; Boehringer Ingelheim; Ministry of Health, Ontario","keywords":"Biology; Phosphorylation; Chromatin; Protein subunit; Phosphatase; Gene; Transcription factor; Protein phosphatase 1; Cell biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009439985,0.000265335,0.0001514726,0.00009838738,0.0001562767,0.0002063548,0.0001378308,0.000136914,0.001224292],"category_scores_gemma":[0.0001259983,0.0001209021,0.0001560802,0.00008122756,0.0002181757,0.00017361,0.0003069625,0.0003007711,0.0004934443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263854,"about_ca_system_score_gemma":0.0001578463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004797724,"about_ca_topic_score_gemma":0.001041331,"domain_scores_codex":[0.9999462,0.000007805697,0.000002531013,0.00001529421,0.00001910862,0.000009036685],"domain_scores_gemma":[0.9999599,0.00001081562,0.00001144622,0.000002653831,0.000002774118,0.00001239908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007641397,0.000009393401,0.0006627846,0.00005174211,0.000007841702,0.00007153245,0.00001045912,0.0001756001,0.9962224,0.000336481,0.00005313758,0.002322369],"study_design_scores_gemma":[0.00001521229,0.000138458,0.006807943,0.000006835498,0.000008113005,0.0005246944,0.00002625792,0.002526115,0.9823748,0.0002281205,0.007336434,0.000006903525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830045,0.003201419,0.01109192,0.0001134891,0.00002300132,0.00002245811,0.0001496274,0.00009544701,0.002298278],"genre_scores_gemma":[0.9916558,0.001376589,0.004487919,0.00004097897,0.00001512859,0.00001098378,0.0002840999,0.00001376561,0.002114782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224292,"threshold_uncertainty_score":0.004095614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03726030669306084,"score_gpt":0.3315326932279275,"score_spread":0.2942723865348666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}