{"id":"W4214492388","doi":"10.1093/nar/gkac138","title":"The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Sunnybrook Health Science Centre","funders":"Janssen Biotech; Canadian Institutes of Health Research; Genentech; Pfizer; Vetenskapsrådet; Linköpings Universitet; Barncancerfonden; Merck KGaA; Genome Canada; Bristol-Myers Squibb Canada; Cancerfonden; Bayer; Princess Margaret Cancer Foundation; Takeda Pharmaceuticals U.S.A.; National Supercomputer Centre, Linköpings Universitet; Boehringer Ingelheim; Ministry of Health, Ontario","keywords":"Biology; Phosphorylation; Chromatin; Protein subunit; Phosphatase; Gene; Transcription factor; Protein phosphatase 1; Cell biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001324483,0.0001654624,0.0001345318,0.00009496777,0.00102801,0.000145857,0.0007682262,0.00007076078,0.0006018687],"category_scores_gemma":[0.0006411548,0.0001200503,0.00005609601,0.0005213105,0.0001316813,0.00001158518,0.0008699984,0.0005169506,0.0002046524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414698,"about_ca_system_score_gemma":0.0002728924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007805904,"about_ca_topic_score_gemma":0.00006647933,"domain_scores_codex":[0.997314,0.0004960091,0.0002308503,0.0004869188,0.0009001925,0.0005720729],"domain_scores_gemma":[0.9986888,0.0000715597,0.00006523535,0.0006776895,0.0002549787,0.0002417725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001129705,0.0001533398,0.0001586381,0.00002098034,0.00006012495,0.00002876461,0.0002994397,0.00002240974,0.8355817,0.0003721366,0.1219749,0.04019784],"study_design_scores_gemma":[0.0003325337,0.0009438014,0.0002584755,0.00001487744,0.000001644218,0.000009581557,0.0002725662,0.00003303837,0.513167,0.0000144524,0.4848368,0.0001151944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883145,0.001311666,0.00005703252,0.003550791,0.0001917668,0.001445113,0.0001220969,0.0000365293,0.004970483],"genre_scores_gemma":[0.9882255,0.00009091915,0.0003396052,0.0004428052,0.0002028039,0.0007634537,0.0001428236,0.0000475002,0.009744655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3628619,"threshold_uncertainty_score":0.7906728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03726030669306084,"score_gpt":0.3315326932279275,"score_spread":0.2942723865348666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}