{"id":"W4214496408","doi":"10.1007/s00262-022-03169-6","title":"Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University; National Center for Advancing Translational Sciences; Institute for Clinical and Translational Research, University of Wisconsin, Madison; National Cancer Institute; National Institutes of Health; ECOG-ACRIN Cancer Research Group; LUNGevity Foundation; Bristol-Myers Squibb; International Association for the Study of Lung Cancer","keywords":"Biology; Microbiome; Human microbiome; Immune system; Humanized mouse; Feces; Human Microbiome Project; Immunology; Microbiology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724135,0.0005817675,0.000319294,0.0006478646,0.0002189735,0.0005070572,0.0001612434,0.0004348358,0.002838235],"category_scores_gemma":[0.0001973206,0.0002438526,0.0004856057,0.0002020435,0.0004263379,0.0002614773,0.0002520617,0.001199372,0.0005647956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003801803,"about_ca_system_score_gemma":0.0003462812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003061745,"about_ca_topic_score_gemma":0.001085126,"domain_scores_codex":[0.999698,0.00003952477,0.00001239519,0.00008614368,0.00006348494,0.0001003646],"domain_scores_gemma":[0.9998281,0.00001613328,0.00007218419,0.00002062238,0.00001349348,0.00004940952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002004161,0.0004183898,0.001065982,0.00004363927,0.00001141788,0.00006359294,0.00003501916,0.0001472445,0.9931151,0.0001568245,0.0001415673,0.002797059],"study_design_scores_gemma":[0.0002316208,0.005529366,0.02007453,0.0000367547,0.00009292658,0.0004376529,0.0003950344,0.00199951,0.966811,0.000298188,0.004077123,0.00001636836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926085,0.0008366499,0.003746442,0.0002166241,0.0001087057,0.00009601679,0.0008043563,0.0001407612,0.001441916],"genre_scores_gemma":[0.992105,0.0005231783,0.002625632,0.0001751534,0.00002692034,0.000174281,0.0006292928,0.00004945331,0.003691022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002838235,"threshold_uncertainty_score":0.009494781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024396180600617,"score_gpt":0.2630004640901598,"score_spread":0.2427565022841536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}