{"id":"W4214500137","doi":"10.1093/hmg/ddac050","title":"Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes","year":2022,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Gestational Diabetes Research and Management","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Ontario Genomics; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"CHIST-ERA; Vetenskapsrådet; Horizon 2020 Framework Programme; National Institutes of Health; Conseil Régional Hauts-de-France; Novo Nordisk Fonden; Sigrid Juséliuksen Säätiö; European Genomic Institute for Diabetes; Norges Forskningsråd; AstraZeneca; European Commission; Socialdepartementet; Centre for Medical Systems Biology; Novo Nordisk; Juho Vainion Säätiö; Korea Health Industry Development Institute; Suomen Lääketieteen Säätiö; Diabetesforbundet; University of Exeter; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Shanghai Jiao Tong University; Päivikki ja Sakari Sohlbergin Säätiö; Eesti Teadusagentuur; European Regional Development Fund; Terveyden ja hyvinvoinnin laitos; Academy of Finland; University of Bristol; ZonMw; British Heart Foundation; Impact Fund; Fondation Francophone pour la Recherche sur le Diabète; Croucher Foundation; Tartu Ülikool; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Signe ja Ane Gyllenbergin Säätiö; Diabète Québec; Oulun Yliopisto; Joint Programming Initiative A healthy diet for a healthy life; Lastentautien Tutkimussäätiö; National Institute for Health and Care Research; Medical Research Center Oulu; Agence Nationale de la Recherche; Wellcome Trust; American Diabetes Association; Jane ja Aatos Erkon Säätiö; Yrjö Jahnssonin Säätiö; Helsingin Yliopisto; Chinese University of Hong Kong; Eli Lilly and Company","keywords":"Gestational diabetes; Genome-wide association study; Biology; Mendelian randomization; Type 2 diabetes; TCF7L2; Genetic association; Genetics; Bioinformatics; Pregnancy; Diabetes mellitus; Endocrinology; Genotype; Single-nucleotide polymorphism; Gestation; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000344896,0.0005146728,0.001361559,0.000484371,0.0001788003,0.00005777393,0.0003921973,0.0002694183,0.0004179467],"category_scores_gemma":[0.0002186262,0.0004531581,0.0002587436,0.000626337,0.0000749734,0.00002847143,0.0002412188,0.0007616557,0.00003202806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004558885,"about_ca_system_score_gemma":0.0004372461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008208103,"about_ca_topic_score_gemma":0.0000141918,"domain_scores_codex":[0.9956915,0.0004583288,0.0008667538,0.0006983962,0.00166355,0.0006215067],"domain_scores_gemma":[0.9975502,0.0003790316,0.0007219081,0.0006754969,0.0004400756,0.0002332438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001513485,0.02540789,0.2965891,0.1536093,0.04527863,0.002129478,0.0023482,0.008381504,0.002102386,0.0003591968,0.004234678,0.4594083],"study_design_scores_gemma":[0.002217998,0.004765353,0.1687912,0.00151676,0.004910804,0.000001303067,0.00009875549,0.00008820104,0.00004872989,0.00005281566,0.816703,0.0008050317],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1507859,0.8462199,0.00004271442,0.00002519353,0.00009325505,0.002602223,0.00006710106,0.00003779095,0.0001259404],"genre_scores_gemma":[0.007749377,0.9846308,0.003566553,0.0001518062,0.00009565768,0.0006212727,0.002209988,0.0001621229,0.0008124168],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8124683,"threshold_uncertainty_score":0.999792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05253414681382092,"score_gpt":0.3335375890651156,"score_spread":0.2810034422512947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}