{"id":"W4214500137","doi":"10.1093/hmg/ddac050","title":"Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes","year":2022,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Gestational Diabetes Research and Management","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Ontario Genomics; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"CHIST-ERA; Vetenskapsrådet; Horizon 2020 Framework Programme; National Institutes of Health; Conseil Régional Hauts-de-France; Novo Nordisk Fonden; Sigrid Juséliuksen Säätiö; European Genomic Institute for Diabetes; Norges Forskningsråd; AstraZeneca; European Commission; Socialdepartementet; Centre for Medical Systems Biology; Novo Nordisk; Juho Vainion Säätiö; Korea Health Industry Development Institute; Suomen Lääketieteen Säätiö; Diabetesforbundet; University of Exeter; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Shanghai Jiao Tong University; Päivikki ja Sakari Sohlbergin Säätiö; Eesti Teadusagentuur; European Regional Development Fund; Terveyden ja hyvinvoinnin laitos; Academy of Finland; University of Bristol; ZonMw; British Heart Foundation; Impact Fund; Fondation Francophone pour la Recherche sur le Diabète; Croucher Foundation; Tartu Ülikool; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Signe ja Ane Gyllenbergin Säätiö; Diabète Québec; Oulun Yliopisto; Joint Programming Initiative A healthy diet for a healthy life; Lastentautien Tutkimussäätiö; National Institute for Health and Care Research; Medical Research Center Oulu; Agence Nationale de la Recherche; Wellcome Trust; American Diabetes Association; Jane ja Aatos Erkon Säätiö; Yrjö Jahnssonin Säätiö; Helsingin Yliopisto; Chinese University of Hong Kong; Eli Lilly and Company","keywords":"Gestational diabetes; Genome-wide association study; Biology; Mendelian randomization; Type 2 diabetes; TCF7L2; Genetic association; Genetics; Bioinformatics; Pregnancy; Diabetes mellitus; Endocrinology; Genotype; Single-nucleotide polymorphism; Gestation; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001898905,0.0004935916,0.0008309346,0.001371766,0.0008105804,0.001281249,0.0006281207,0.000872503,0.001967602],"category_scores_gemma":[0.005114561,0.0003559425,0.002162719,0.003249863,0.0003708374,0.0003510361,0.001039301,0.001524233,0.000134789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003452052,"about_ca_system_score_gemma":0.0004569451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01245687,"about_ca_topic_score_gemma":0.01504447,"domain_scores_codex":[0.998202,0.0006664256,0.0001699995,0.000648185,0.0001713946,0.0001420205],"domain_scores_gemma":[0.9972615,0.00114203,0.0006445091,0.000450078,0.000209665,0.0002922241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0008933722,0.00002683835,0.9795405,0.0001113009,0.003743709,0.0006023603,0.0001899567,0.0003199389,0.00280615,0.0002894095,0.0006066362,0.01086996],"study_design_scores_gemma":[0.00003747176,0.00005696129,0.9945185,0.00003801057,0.00228738,0.0005705624,0.0001114397,0.0007698491,0.0003451717,0.0004072064,0.0008453135,0.000012274],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9866689,0.008089006,0.001826129,0.0008265192,0.0001061725,0.00001280978,0.00104435,0.00004590169,0.001380138],"genre_scores_gemma":[0.9967393,0.001289196,0.00109793,0.0001613134,0.00005136286,0.000009856769,0.0003966074,0.00001695443,0.0002374718],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01245687,"threshold_uncertainty_score":0.02476871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05253414681382092,"score_gpt":0.3335375890651156,"score_spread":0.2810034422512947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}