{"id":"W4214503098","doi":"10.1016/j.celrep.2022.110446","title":"Creatine transport and creatine kinase activity is required for CD8+ T cell immunity","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Creatine; T cell; CD8; Creatine kinase; Biology; Homeostasis; Cytotoxic T cell; Cell biology; Cell; Naive T cell; Immune system; Endocrinology; T-cell receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004557318,0.000215793,0.0003184038,0.0001070154,0.0007682396,0.00001269459,0.00008529113,0.0001328516,0.005501195],"category_scores_gemma":[0.00004133537,0.0002213764,0.0001646791,0.000118216,0.00008927086,0.0001409227,0.00008207822,0.0004149956,0.00002439124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007781813,"about_ca_system_score_gemma":0.00007847401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004403986,"about_ca_topic_score_gemma":0.000006861321,"domain_scores_codex":[0.9986231,0.0001462662,0.0004358053,0.0004345397,0.0000564701,0.0003037805],"domain_scores_gemma":[0.9989005,0.0001165313,0.0003832366,0.0004782666,0.00008762594,0.00003379393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008563893,0.0005810171,0.002870046,0.00006836428,0.00005465892,0.00005338347,0.0006551985,0.00001302207,0.9676294,0.00001126451,0.02588868,0.001318587],"study_design_scores_gemma":[0.00108254,0.0005383253,0.002845892,0.000007358286,0.00009068562,0.0003647499,0.000505191,0.00001848444,0.6302395,0.00004874895,0.3640344,0.0002241241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750793,0.001375004,0.0004270165,0.0001967823,0.003127376,0.0005565013,0.00002455925,0.0001014299,0.01911202],"genre_scores_gemma":[0.8821819,0.00006213062,0.00005125684,0.0002398764,0.00002600202,0.000155274,0.0004247526,0.00002772669,0.1168311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3381458,"threshold_uncertainty_score":0.9954079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378812746005711,"score_gpt":0.2338858217465105,"score_spread":0.2200976942864534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}