{"id":"W4214507203","doi":"10.3390/curroncol29030126","title":"Real-World Evidence of Systemic Therapy Sequencing on Overall Survival for Patients with Metastatic BRAF-Mutated Cutaneous Melanoma","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Queen's University","funders":"","keywords":"Metastatic melanoma; Medicine; Systemic therapy; Melanoma; Overall survival; Oncology; Targeted therapy; Vemurafenib; Cancer research; Internal medicine; Bioinformatics; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003626449,0.0001722142,0.0003271801,0.0002702021,0.0002029877,0.0006533294,0.0003311959,0.0003998371,0.001692292],"category_scores_gemma":[0.009752623,0.0001032802,0.0007562739,0.0004748036,0.00037932,0.0003978295,0.0002895264,0.0004159829,0.00009286249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001166332,"about_ca_system_score_gemma":0.00145847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007720206,"about_ca_topic_score_gemma":0.01939599,"domain_scores_codex":[0.9981553,0.001047241,0.0001573935,0.0002541466,0.0002895939,0.00009625363],"domain_scores_gemma":[0.9905803,0.005381716,0.002854683,0.0003634936,0.0004789495,0.0003408219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0118178,0.0002035216,0.8998874,0.001046636,0.002521192,0.0000781682,0.0001250462,0.001945221,0.0008036426,0.0001778329,0.001420835,0.07997265],"study_design_scores_gemma":[0.0005570264,0.002466108,0.9882094,0.0003928436,0.002561395,0.0002439579,0.0001897753,0.001603179,0.0003390747,0.0002188872,0.003196759,0.00002159887],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705375,0.0247261,0.0003804412,0.001084041,0.00006228552,0.00002890524,0.001148199,0.00001115101,0.002021449],"genre_scores_gemma":[0.99723,0.001496286,0.000257713,0.0002679035,0.00003607613,0.00001226631,0.0006245286,0.000002971394,0.00007243925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007720206,"threshold_uncertainty_score":0.01917875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08902090121553219,"score_gpt":0.3500544874061776,"score_spread":0.2610335861906454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}