{"id":"W4214511712","doi":"10.1210/clinem/dgac105","title":"The Efficacy, Safety, and Pharmacology of a Ghrelin O-Acyltransferase Inhibitor for the Treatment of Prader-Willi Syndrome","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Alberta; Centre Hospitalier de l’Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Eli Lilly and Company","keywords":"Placebo; Medicine; Adverse effect; Pharmacodynamics; Internal medicine; Pharmacokinetics; Ghrelin; Appetite; Crossover study; Endocrinology; Obesity; Clinical trial; Pharmacology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006302512,0.0004544963,0.0007664918,0.0002444772,0.0001878576,0.0002980718,0.0003864556,0.0004865157,0.001294191],"category_scores_gemma":[0.0006654264,0.0002169559,0.0004818561,0.0001767165,0.0005252618,0.0003887231,0.0001534337,0.001249274,0.0002089552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201182,"about_ca_system_score_gemma":0.0004769221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004103468,"about_ca_topic_score_gemma":0.001028798,"domain_scores_codex":[0.9997844,0.0001051748,0.00002268653,0.00002743286,0.00003403849,0.00002621109],"domain_scores_gemma":[0.9997037,0.00009641417,0.00009616704,0.00001501289,0.00001711314,0.00007145104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3532916,0.0289214,0.03486725,0.001658287,0.001340548,0.00114198,0.0004613562,0.001765139,0.2811111,0.0002416161,0.001067366,0.2941323],"study_design_scores_gemma":[0.1553773,0.65887,0.1457444,0.00008707183,0.001090138,0.001727471,0.0002090444,0.001606926,0.03205063,0.00009632798,0.003092794,0.00004791301],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966812,0.002442156,0.0001774124,0.0001082504,0.00002150427,0.0001222595,0.00006863886,0.00001639667,0.0003620884],"genre_scores_gemma":[0.9974797,0.001404443,0.0004191211,0.0001302968,0.00006506447,0.0001071271,0.0001558152,0.000003886512,0.0002345541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294191,"threshold_uncertainty_score":0.004329503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03070680707183707,"score_gpt":0.3471978001677184,"score_spread":0.3164909930958813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}