{"id":"W4214511712","doi":"10.1210/clinem/dgac105","title":"The Efficacy, Safety, and Pharmacology of a Ghrelin O-Acyltransferase Inhibitor for the Treatment of Prader-Willi Syndrome","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Alberta; Centre Hospitalier de l’Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Eli Lilly and Company","keywords":"Placebo; Medicine; Adverse effect; Pharmacodynamics; Internal medicine; Pharmacokinetics; Ghrelin; Appetite; Crossover study; Endocrinology; Obesity; Clinical trial; Pharmacology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00156983,0.0001591719,0.0006182924,0.00003713615,0.0003194813,0.000005430555,0.0005297066,0.00007248072,0.00003092834],"category_scores_gemma":[0.0003100244,0.00007749,0.000430894,0.00007821498,0.0006569818,0.000002978758,0.0001663666,0.0002812524,3.202252e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006545371,"about_ca_system_score_gemma":0.000153559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001634039,"about_ca_topic_score_gemma":0.000004450573,"domain_scores_codex":[0.9972152,0.0007771362,0.001359332,0.0001670724,0.0001767573,0.0003045425],"domain_scores_gemma":[0.9966544,0.002028918,0.000776572,0.0003283735,0.0001441242,0.00006760405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005542777,0.004145585,0.009014182,0.00009334459,0.009087158,0.00002438982,0.001801879,0.004268082,0.5027909,0.00163219,0.003496079,0.4581034],"study_design_scores_gemma":[0.0119216,0.009940615,0.09941381,0.000009484332,0.001627144,0.002312231,0.0009453251,0.0001271608,0.05111878,0.0002544132,0.82215,0.0001794138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631732,0.0286264,0.0003939603,0.005817773,0.001480633,0.0004645059,0.00002897795,0.000001868885,0.00001270888],"genre_scores_gemma":[0.9517108,0.04713107,0.0002332387,0.0002551569,0.0005148681,0.00002206325,0.000002407172,0.00001702338,0.0001133421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8186539,"threshold_uncertainty_score":0.3159951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03070680707183707,"score_gpt":0.3471978001677184,"score_spread":0.3164909930958813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}