{"id":"W4214535119","doi":"10.37766/inplasy2022.2.0113","title":"Efficacy of CoQ10 supplementation for the treatment of primary CoQ10 deficiency","year":2022,"lang":"en","type":"report","venue":"","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Coenzyme Q10; Mitochondrial respiratory chain; Respiratory chain; Mitochondrial disease; Coenzyme Q – cytochrome c reductase; Disease; Gene; Bioinformatics; Medicine; Mitochondrial DNA; Biology; Pediatrics; Mitochondrion; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559758,0.0001911098,0.0003525872,0.00003313316,0.0001152478,0.000004368293,0.0001489403,0.00009330371,0.0001990728],"category_scores_gemma":[0.00005761712,0.0001248516,0.0003421974,0.00006627552,0.00007060376,6.080357e-7,0.00009850739,0.00003564535,3.313154e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100179,"about_ca_system_score_gemma":0.0004412012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004752185,"about_ca_topic_score_gemma":0.0001608664,"domain_scores_codex":[0.9988396,0.0000320049,0.0003686417,0.0002854322,0.0002996397,0.0001747234],"domain_scores_gemma":[0.9989155,0.0001634554,0.0003131058,0.0003919752,0.0001952976,0.00002068932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001003457,0.001709719,0.001088916,0.0009332243,0.001261652,0.000002037642,0.0003177897,0.0002595395,0.05394089,0.00008195738,0.8925641,0.04683669],"study_design_scores_gemma":[0.001755654,0.004960299,0.002402644,0.00001227347,0.0004193129,0.000008394661,0.0002626987,0.00001078482,0.05187629,0.000002911505,0.9381135,0.0001752678],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6973149,0.1839595,0.006038174,0.001165689,0.006748559,0.01912913,0.007772249,0.00005817189,0.07781366],"genre_scores_gemma":[0.800971,0.1350635,0.001330362,0.0001946426,0.001624441,0.002379551,0.01754881,0.0001630693,0.04072463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1036561,"threshold_uncertainty_score":0.50913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03094150826731343,"score_gpt":0.3236649001657818,"score_spread":0.2927233918984684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}