{"id":"W4214553767","doi":"10.1186/s13054-022-03901-9","title":"Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial","year":2022,"lang":"en","type":"article","venue":"Critical Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Universitätsklinikum Jena; Bundesministerium für Bildung und Forschung","keywords":"Medicine; Sepsis; Confounding; Clinical endpoint; Septic shock; Antimicrobial; Randomized controlled trial; Surviving Sepsis Campaign; Internal medicine; Adverse effect; Emergency medicine; Severe sepsis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02187448,0.002408964,0.006824153,0.0007519926,0.0005251975,0.0017245,0.001570684,0.002175784,0.004695682],"category_scores_gemma":[0.03251495,0.0008167353,0.01109047,0.0008133856,0.001326101,0.001563918,0.001153483,0.00248495,0.0003873598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001519286,"about_ca_system_score_gemma":0.00240332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157518,"about_ca_topic_score_gemma":0.001112128,"domain_scores_codex":[0.9815086,0.01332856,0.001310589,0.002237369,0.0008352709,0.0007796444],"domain_scores_gemma":[0.964084,0.02193824,0.007024442,0.003291596,0.00218294,0.001478754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9702707,0.001255519,0.002758946,0.00217264,0.01810296,0.00003418052,0.00004420492,0.0009960763,0.0003328107,0.0001564183,0.0004076978,0.003467863],"study_design_scores_gemma":[0.8705267,0.07148372,0.0129682,0.0003121623,0.03629558,0.00007181882,0.00007174318,0.005691356,0.0007366636,0.001123267,0.0006317327,0.00008700469],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697464,0.01078081,0.006262147,0.000708498,0.001400956,0.007338657,0.00224619,0.0002522056,0.001264159],"genre_scores_gemma":[0.9852886,0.00110506,0.005012227,0.0004137662,0.0003632707,0.006297579,0.0008747622,0.00003970649,0.0006050697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02187448,"threshold_uncertainty_score":0.1156847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045572027166003,"score_gpt":0.2874939314982677,"score_spread":0.2770382112266077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}