{"id":"W4214572776","doi":"10.1101/2022.02.25.482019","title":"DLK-dependent biphasic reactivation of herpes simplex virus latency established in the absence of antivirals","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; Owens Family Foundation; Deutsches Zentrum für Infektionsforschung; University of Pennsylvania","keywords":"Herpes simplex virus; Lytic cycle; Biology; Virology; Viral replication; Virus; Latent Virus; Virus latency; Histone; Demethylase; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105718,0.0002237421,0.0002401144,0.0001860311,0.00009693129,0.0003131357,0.0002343954,0.0001403742,0.001649043],"category_scores_gemma":[0.0001851744,0.0001162712,0.000196192,0.000143671,0.000139899,0.0002505981,0.0002314566,0.0004474188,0.0004003076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005432164,"about_ca_system_score_gemma":0.0001996682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007117192,"about_ca_topic_score_gemma":0.0008475771,"domain_scores_codex":[0.999871,0.00001676011,0.00001510654,0.00002447346,0.00003436299,0.00003824208],"domain_scores_gemma":[0.9998863,0.00002889487,0.00002620768,0.00001694374,0.00001942468,0.00002219266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002027686,0.00002327277,0.0001664968,0.00004332218,0.000002888907,0.00001683988,0.00001209555,0.00005139119,0.9982883,0.00008017088,0.00003144106,0.001080964],"study_design_scores_gemma":[0.00001404504,0.0001965456,0.003961953,0.000007277157,0.00000476286,0.00006555778,0.00002367847,0.0008722348,0.9937874,0.00005147063,0.001010643,0.000004352809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906715,0.002954287,0.003278198,0.00005405164,0.00003862211,0.00005889731,0.0008357256,0.0001190454,0.001989697],"genre_scores_gemma":[0.9952484,0.0005691631,0.001410611,0.00003123819,0.000006557378,0.00005154237,0.0005285846,0.00001716878,0.002136705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649043,"threshold_uncertainty_score":0.005516648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02326032246475696,"score_gpt":0.2696683074539424,"score_spread":0.2464079849891854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}