{"id":"W4214573195","doi":"10.1038/s43018-022-00332-x","title":"The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology","year":2022,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Principia Biopharma; Loxo Oncology; Pharmacyclics; Chugai Pharmaceutical; Genentech; Foundation Medicine; Sierra Oncology; Menarini Group; PharmaMar; Novartis Farmacéutica; Daiichi Sankyo Europe; Servier; Stockholms Läns Landsting; Karolinska Institutet; Eisai; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; National Institute for Health and Care Research; European Bioinformatics Institute; Seagen; MacroGenics; BeiGene; Medical Research Council; Les Laboratories Pierre Fabre; University of Cambridge; Cancer Research UK; Spectrum Pharmaceuticals; Ipsen; Array BioPharma; Symphogen; Pfizer; Incyte; F. Hoffmann-La Roche; European Commission; Science for Life Laboratory; Halozyme; Exelixis; Sanofi; GlaxoSmithKline; Amgen; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Precision oncology; Medical physics; Clinical Oncology; Medicine; Oncology; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018405,0.0001241263,0.0002013117,0.00002297274,0.0004031212,0.00003163294,0.0001838792,0.0001965948,0.00002513858],"category_scores_gemma":[0.002633796,0.00009952198,0.0001493559,0.00007665101,0.00007918938,0.000001905917,0.0003325357,0.000376286,2.973801e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005427236,"about_ca_system_score_gemma":0.0005622901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001655743,"about_ca_topic_score_gemma":0.000155133,"domain_scores_codex":[0.9984329,0.00006841811,0.0006411172,0.0004395384,0.0001631823,0.000254854],"domain_scores_gemma":[0.9985363,0.0003057909,0.0005722875,0.0003376872,0.0001446834,0.0001032446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001789379,0.0002595904,0.02241791,0.00002160763,0.0003772556,0.0004163562,0.00008668406,0.001847496,0.08973235,0.001938324,0.7006009,0.1805121],"study_design_scores_gemma":[0.0007572879,0.0005590001,0.005255315,0.000007555713,0.00005387671,0.0001107393,0.0000889551,0.0008297128,0.005440054,0.0004149289,0.9863098,0.0001727275],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784691,0.01637582,0.0002715832,0.001458365,0.002207613,0.0005457811,0.0002128128,0.00002998255,0.0004289372],"genre_scores_gemma":[0.9936633,0.001443037,0.001133063,0.002616334,0.0004041649,0.0003443965,0.0001416184,0.00003172395,0.0002223234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2857089,"threshold_uncertainty_score":0.4058388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675761238946715,"score_gpt":0.3856319906093343,"score_spread":0.3688743782198672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}