{"id":"W4214573195","doi":"10.1038/s43018-022-00332-x","title":"The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology","year":2022,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Principia Biopharma; Loxo Oncology; Pharmacyclics; Chugai Pharmaceutical; Genentech; Foundation Medicine; Sierra Oncology; Menarini Group; PharmaMar; Novartis Farmacéutica; Daiichi Sankyo Europe; Servier; Stockholms Läns Landsting; Karolinska Institutet; Eisai; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; National Institute for Health and Care Research; European Bioinformatics Institute; Seagen; MacroGenics; BeiGene; Medical Research Council; Les Laboratories Pierre Fabre; University of Cambridge; Cancer Research UK; Spectrum Pharmaceuticals; Ipsen; Array BioPharma; Symphogen; Pfizer; Incyte; F. Hoffmann-La Roche; European Commission; Science for Life Laboratory; Halozyme; Exelixis; Sanofi; GlaxoSmithKline; Amgen; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Precision oncology; Medical physics; Clinical Oncology; Medicine; Oncology; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01351851,0.001073254,0.001040086,0.003661048,0.001021992,0.007262242,0.002274619,0.001799707,0.04501307],"category_scores_gemma":[0.04608008,0.0007620815,0.0007382969,0.002813651,0.0009213107,0.006928473,0.007161469,0.002444989,0.023001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137989,"about_ca_system_score_gemma":0.003739813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0018416,"about_ca_topic_score_gemma":0.001399216,"domain_scores_codex":[0.9875909,0.006578228,0.001239977,0.001476155,0.002592538,0.000522282],"domain_scores_gemma":[0.9590659,0.0196228,0.00327931,0.008912372,0.005500838,0.003618752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001912115,0.0003978818,0.01052938,0.0008209494,0.0001666979,0.0009710739,0.001643978,0.004816115,0.006119314,0.02831321,0.3611066,0.5832026],"study_design_scores_gemma":[0.0006113849,0.000286633,0.005272043,0.0005820007,0.00008710838,0.0009282402,0.0004662931,0.0364491,0.0107727,0.04762505,0.8966796,0.0002399043],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01788366,0.00232544,0.6806335,0.01389727,0.001929579,0.001764963,0.01510492,0.2080862,0.0583744],"genre_scores_gemma":[0.2540637,0.002892545,0.6642742,0.005428874,0.002640558,0.00209632,0.02545229,0.02024518,0.02290655],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.04501307,"threshold_uncertainty_score":0.1505837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675761238946715,"score_gpt":0.3856319906093343,"score_spread":0.3688743782198672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}