{"id":"W4214574635","doi":"10.3389/fphys.2022.827435","title":"The Cellular and Developmental Roles of Cullins, Neddylation, and the COP9 Signalosome in Dictyostelium discoideum","year":2022,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Trent University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neddylation; NEDD8; COP9 signalosome; Cullin; Dictyostelium discoideum; Biology; Cell biology; Multicellular organism; Ubiquitin; Biochemistry; Ubiquitin ligase; Cell; Gene; Protease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100485,0.0003065711,0.0002078234,0.0004246491,0.0003560209,0.0004511454,0.0002117327,0.0002636814,0.0002685978],"category_scores_gemma":[0.000108794,0.0002031372,0.0002293168,0.0002528804,0.0003748019,0.0003593437,0.0004598844,0.000303942,0.0001685489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001016797,"about_ca_system_score_gemma":0.0004714997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004946523,"about_ca_topic_score_gemma":0.005830503,"domain_scores_codex":[0.9999063,0.000006522103,0.00001186877,0.0000349286,0.00002047857,0.00001981522],"domain_scores_gemma":[0.9999499,0.000003657137,0.00001554131,0.000004090389,0.000009318596,0.00001756499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001745404,0.000008790325,0.002753744,0.0002330453,0.00001021809,0.0004566545,0.0001075226,0.0002388976,0.9859304,0.001144245,0.0002441008,0.008697962],"study_design_scores_gemma":[0.00005670355,0.0002781257,0.2495459,0.0001300729,0.0001026647,0.002214195,0.000543726,0.002357203,0.6606546,0.00114767,0.08289602,0.00007310561],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8427366,0.1409631,0.004813025,0.0007367254,0.0001475281,0.00002949179,0.001272364,0.0001419664,0.009159184],"genre_scores_gemma":[0.9687924,0.02165202,0.002193629,0.0001923989,0.00003214422,0.0000246179,0.001104282,0.00001460182,0.005993834],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004946523,"threshold_uncertainty_score":0.009835482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283813996792878,"score_gpt":0.2373950048309315,"score_spread":0.2245568648630027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}