{"id":"W4214575951","doi":"10.1111/epi.17186","title":"Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways","year":2022,"lang":"en","type":"article","venue":"Epilepsia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Agence Nationale de la Recherche; Université de Montpellier; Fondation Vaincre Alzheimer","keywords":"Epileptogenesis; Translocator protein; Status epilepticus; Hyperphosphorylation; Neuroinflammation; Hippocampus; Kainic acid; Neuroscience; Epilepsy; Gliosis; Entorhinal cortex; Psychology; Neurodegeneration; Medicine; Inflammation; Pathology; Internal medicine; Phosphorylation; Chemistry; Receptor; Disease; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007083212,0.00031513,0.0001843912,0.0001951182,0.0001039726,0.0001762457,0.00007043324,0.0001777421,0.001099833],"category_scores_gemma":[0.0001485075,0.00006302723,0.0002154114,0.0001500617,0.0002092521,0.0001599648,0.0002022474,0.0002559205,0.0001749744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001974166,"about_ca_system_score_gemma":0.0001193796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000308135,"about_ca_topic_score_gemma":0.0005098648,"domain_scores_codex":[0.9999076,0.0000157102,0.00001121752,0.00001597246,0.00002009866,0.00002929689],"domain_scores_gemma":[0.9999083,0.00001417419,0.00004084585,0.00001153249,0.00001009876,0.0000149736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007793575,0.00008770527,0.002971919,0.0001122398,0.00002327634,0.0005610934,0.0000390488,0.0001138791,0.9917671,0.0001255435,0.00008112619,0.003337655],"study_design_scores_gemma":[0.0001284298,0.003055622,0.1691906,0.00005529115,0.0001044842,0.003780167,0.000242224,0.001308667,0.8188104,0.0006148188,0.002691406,0.00001787553],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996852,0.001573284,0.000613872,0.00004048162,0.00001456315,0.00001954309,0.0001326499,0.00004167212,0.0007119415],"genre_scores_gemma":[0.9986587,0.0006053067,0.0001987972,0.00002331615,0.000008792524,0.0000238932,0.0001443589,0.000003004285,0.0003339714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099833,"threshold_uncertainty_score":0.003679276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863955091184202,"score_gpt":0.2764823444675061,"score_spread":0.2478427935556641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}