{"id":"W4214584206","doi":"10.1053/j.gastro.2022.02.036","title":"Design of Clinical Trials for Mild to Moderate Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Calgary Laboratory Services; University of Calgary; Alberta Health Services","funders":"Norgine; Dr. Falk Pharma; Tillotts Pharma; Ferring Pharmaceuticals; Western University; Shire; Novo Nordisk; Kyowa Hakko Kirin; Center for AIDS Research, University of California, San Diego; Universiteit van Amsterdam; Celltrion; Boston Pharmaceuticals; Mylan; Takeda Pharmaceutical Company; AbbVie; Teva Pharmaceutical Industries; Janssen Pharmaceuticals; Ablynx; Gilead Sciences; GlaxoSmithKline; Merck; Otsuka America; Celgene; Pfizer; Biogen; Allergan; AstraZeneca; Seres Therapeutics; Genentech; Hospira; Boehringer Ingelheim; Amgen; Eli Lilly and Company; Samsung; Bristol-Myers Squibb","keywords":"Crohn's disease; Medicine; Clinical trial; Disease; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02216063,0.002654385,0.005334356,0.001305449,0.001309512,0.002132959,0.001219531,0.002929495,0.009872824],"category_scores_gemma":[0.02044007,0.001125623,0.002792465,0.0007719222,0.001925248,0.001230565,0.001276531,0.003022231,0.001458919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001806826,"about_ca_system_score_gemma":0.003857379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005700858,"about_ca_topic_score_gemma":0.001271118,"domain_scores_codex":[0.9766937,0.01914811,0.001142291,0.001160395,0.0006499775,0.001205498],"domain_scores_gemma":[0.9892993,0.004985033,0.00198591,0.0007602716,0.0007594868,0.002210001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9325163,0.005240571,0.002301712,0.002599328,0.002003589,0.0001299985,0.0001467842,0.002002347,0.003419911,0.001307162,0.001998267,0.04633397],"study_design_scores_gemma":[0.7951767,0.181392,0.003914542,0.0003918326,0.001952254,0.00008335945,0.00007517567,0.001556908,0.001167963,0.002604083,0.01163167,0.0000535866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5193147,0.04170338,0.02639245,0.00807008,0.009373538,0.3619449,0.00447534,0.0005783536,0.02814723],"genre_scores_gemma":[0.7047415,0.005994671,0.02861535,0.004446881,0.001528097,0.2468054,0.001264024,0.00005912464,0.006544925],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02216063,"threshold_uncertainty_score":0.1171981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1073783606480744,"score_gpt":0.3779688188981473,"score_spread":0.2705904582500729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}