{"id":"W4214591749","doi":"10.1002/adma.202201095","title":"Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System","year":2022,"lang":"en","type":"article","venue":"Advanced Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"NanoMedicines Innovation Network; FPInnovations; BC Innovation Council; University of British Columbia","funders":"Interreg; European Regional Development Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Science Foundation; Universiteit Leiden; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Mononuclear phagocyte system; Biodistribution; RNA; In vivo; Messenger RNA; Systemic administration; Cell biology; Biology; Nanotechnology; Immunology; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680987,0.0003749918,0.0001341662,0.0001312824,0.00009261011,0.0002472432,0.0001417513,0.0002321817,0.0005227256],"category_scores_gemma":[0.0001408953,0.0001136615,0.0001312401,0.00005501158,0.0002187062,0.0002140077,0.0002223612,0.0002341186,0.000326513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715548,"about_ca_system_score_gemma":0.0002064546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003564306,"about_ca_topic_score_gemma":0.0006159451,"domain_scores_codex":[0.9998932,0.0000231249,0.000006123381,0.00002391222,0.00003589707,0.00001780877],"domain_scores_gemma":[0.9999315,0.00001258714,0.0000284237,0.000006136553,0.00001366123,0.000007701544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001365084,0.000003221516,0.00002675928,0.00001891427,0.000001362274,0.00001867516,0.000005383902,0.00005998395,0.9989574,0.0001275349,0.00001486815,0.0007521862],"study_design_scores_gemma":[0.000004168612,0.0001073134,0.0002302783,0.00000259969,0.000004851508,0.00003921024,0.000005958779,0.0005050956,0.9975488,0.00002645667,0.001523155,0.0000021259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961486,0.00186667,0.02832162,0.0002079951,0.00005323265,0.00009703826,0.0001205104,0.0002323963,0.007614514],"genre_scores_gemma":[0.9845969,0.001121074,0.009169507,0.0001031268,0.00001395628,0.00004965597,0.00009750878,0.00003504807,0.00481324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005227256,"threshold_uncertainty_score":0.001970291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007815361388180344,"score_gpt":0.2246837537452269,"score_spread":0.2168683923570466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}