{"id":"W4214591749","doi":"10.1002/adma.202201095","title":"Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System","year":2022,"lang":"en","type":"article","venue":"Advanced Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"NanoMedicines Innovation Network; FPInnovations; BC Innovation Council; University of British Columbia","funders":"Interreg; European Regional Development Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Science Foundation; Universiteit Leiden; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Mononuclear phagocyte system; Biodistribution; RNA; In vivo; Messenger RNA; Systemic administration; Cell biology; Biology; Nanotechnology; Immunology; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002840696,0.0001526541,0.0001634208,0.0000265571,0.0002765983,0.00005142246,0.0003881971,0.00003410365,0.0002725164],"category_scores_gemma":[0.00004756948,0.0001183167,0.0000593914,0.00007275346,0.00002665027,0.000006412477,0.0003995868,0.00004896696,0.0001152259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000504512,"about_ca_system_score_gemma":0.00004756923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004601826,"about_ca_topic_score_gemma":0.00003825548,"domain_scores_codex":[0.9986786,0.0001967366,0.0002800901,0.0003375663,0.000225533,0.0002814726],"domain_scores_gemma":[0.9992838,0.00001025173,0.00009744968,0.0004573569,0.00009043919,0.00006071661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000329808,0.00002707641,0.00001422675,0.00001937945,0.00003115832,0.00000277219,0.00008152061,0.001103029,0.9948191,0.0001281808,0.002539746,0.0009040017],"study_design_scores_gemma":[0.0003173441,0.0005294778,0.000178523,0.00001623715,0.00002231354,0.00002112703,0.000240637,0.000008880266,0.9472101,0.00002202765,0.05127092,0.0001624021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973462,0.0001633347,0.0001664724,0.0003335437,0.001209358,0.0004110344,0.0001729576,0.00003073674,0.0001663357],"genre_scores_gemma":[0.9976919,0.00006000104,0.0002343596,0.0006684502,0.0003311006,0.0003246324,0.00007198263,0.00002617674,0.000591414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04873117,"threshold_uncertainty_score":0.4824814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007815361388180344,"score_gpt":0.2246837537452269,"score_spread":0.2168683923570466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}