{"id":"W4214609502","doi":"10.1002/alz.12570","title":"CSF biomarkers and plasma p‐tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial design","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Canadian Institutes of Health Research; Alzheimerfonden; Orionin Tutkimussäätiö; Knut och Alice Wallenbergs Stiftelse; EU Joint Programme – Neurodegenerative Disease Research; Instituto de Salud Carlos III; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Wallenberg Centre for Molecular and Translational Medicine; UK Dementia Research Institute; Vetenskapsrådet; Demensförbundet; Parkinsonfonden; Hjärnfonden; International Society for Neurochemistry; BrightFocus Foundation; Gun och Bertil Stohnes Stiftelse; European Regional Development Fund; European Commission; Alzheimer's Drug Discovery Foundation; National Institute on Aging; Alzheimer's Association","keywords":"Cerebrospinal fluid; Clinical trial; Biomarker; Oncology; Positron emission tomography; Medicine; Internal medicine; Amyloid beta; Alzheimer's Disease Neuroimaging Initiative; Disease; Nuclear medicine; Alzheimer's disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.167353,0.0008342711,0.002030562,0.0006996608,0.0004362645,0.001910546,0.0009357504,0.001656157,0.003180607],"category_scores_gemma":[0.1751899,0.0004640885,0.001665684,0.0011124,0.00156123,0.001809844,0.000857423,0.001309093,0.0003870947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006554233,"about_ca_system_score_gemma":0.002879438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001889626,"about_ca_topic_score_gemma":0.0003495287,"domain_scores_codex":[0.8540891,0.1341696,0.005881337,0.002901527,0.002456481,0.0005019204],"domain_scores_gemma":[0.7713786,0.1914774,0.02305342,0.007079286,0.005083231,0.001928007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.2626237,0.001981507,0.3083831,0.0110639,0.01887025,0.000339653,0.001342168,0.009924737,0.00536917,0.008650819,0.005463236,0.3659878],"study_design_scores_gemma":[0.1810205,0.1171902,0.4612437,0.009710994,0.03348171,0.00115748,0.0006080564,0.0580335,0.01208616,0.09542773,0.02949462,0.0005454056],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7693309,0.072185,0.1022229,0.01723316,0.001524005,0.02817738,0.00199935,0.0003885714,0.006938774],"genre_scores_gemma":[0.9246262,0.002571992,0.04600854,0.002423414,0.0004606429,0.02296037,0.0003508201,0.00003626285,0.0005617912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.167353,"threshold_uncertainty_score":0.8850579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2052317267309718,"score_gpt":0.4449909269864564,"score_spread":0.2397592002554846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}