{"id":"W4214623878","doi":"10.1007/7651_2021_456","title":"Immunoassay for Quantitative Detection of Antibody Transcytosis Across the Blood-Brain Barrier In Vitro","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Transcytosis; Chemistry; Chromatography; In vitro; Immunoassay; Tandem mass spectrometry; Antibody; Blood–brain barrier; Mass spectrometry; Biology; Biochemistry; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002956301,0.002674228,0.001326052,0.001908896,0.0007273368,0.001664687,0.002150946,0.002654503,0.003050002],"category_scores_gemma":[0.003454807,0.001006928,0.0007463529,0.001158587,0.000849969,0.001278932,0.0009741334,0.003815752,0.002627706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009525343,"about_ca_system_score_gemma":0.0008281111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009852974,"about_ca_topic_score_gemma":0.001320131,"domain_scores_codex":[0.9960039,0.001658764,0.0002507138,0.0007772387,0.0009304809,0.0003788174],"domain_scores_gemma":[0.996514,0.002170255,0.0002396881,0.0003624138,0.0005281647,0.0001853951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001567498,0.0001609614,0.0003606708,0.0001916707,0.00002852614,0.00004186179,0.00008616096,0.0001159833,0.9900124,0.0007127282,0.0003315438,0.007800729],"study_design_scores_gemma":[0.00008530514,0.000770641,0.002190374,0.00008456247,0.00008610073,0.0005326439,0.00006163755,0.01269418,0.9795622,0.0005080444,0.003382312,0.00004207374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1418485,0.0129783,0.8296616,0.0006978409,0.0008889876,0.0009034936,0.001339547,0.002812031,0.008869701],"genre_scores_gemma":[0.4255355,0.01000724,0.5397096,0.0007180763,0.0004346869,0.001804571,0.002587048,0.0003873353,0.01881607],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003050002,"threshold_uncertainty_score":0.0156346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02892469452740917,"score_gpt":0.4261087804654517,"score_spread":0.3971840859380426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}