{"id":"W4214625110","doi":"10.1016/j.mattod.2022.01.023","title":"Chemically and mechanically defined hyaluronan hydrogels emulate the extracellular matrix for unbiased in vivo and in vitro organoid formation and drug testing in cancer","year":2022,"lang":"en","type":"article","venue":"Materials Today","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Matrigel; In vivo; Organoid; Cell biology; Cancer cell; In vitro; Extracellular matrix; Tumor microenvironment; Cancer research; Biology; Chemistry; Immunology; Cancer; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004515471,0.0003153993,0.0001140188,0.0001906571,0.0001886564,0.0003701182,0.0002184342,0.0003604491,0.0006867726],"category_scores_gemma":[0.0002989073,0.0001884911,0.0001170906,0.0001820815,0.0002989837,0.0003097907,0.0002507546,0.0003995569,0.0001780445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253988,"about_ca_system_score_gemma":0.0002628854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003385925,"about_ca_topic_score_gemma":0.00118911,"domain_scores_codex":[0.9997401,0.00008214403,0.00001882857,0.00003488881,0.0000905425,0.00003351677],"domain_scores_gemma":[0.9997814,0.00006505936,0.00007208107,0.0000317511,0.00002709885,0.00002261371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002403035,0.00001210421,0.0001145987,0.0000172882,0.000001861472,0.00001457417,0.00001243186,0.0001468793,0.9984367,0.0002362525,0.00001612675,0.0009670541],"study_design_scores_gemma":[0.000003342609,0.00003223522,0.0003619997,0.000001700415,0.000003342558,0.00003354625,0.000007600633,0.0006461,0.9983422,0.00003091586,0.0005344073,0.000002601083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560929,0.001727537,0.03841159,0.0001158623,0.00004065002,0.0001014948,0.0002807311,0.0001009581,0.003128231],"genre_scores_gemma":[0.9649353,0.000715947,0.03171946,0.0000807524,0.00001008792,0.0001039022,0.0001710138,0.00005148716,0.002211993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006867726,"threshold_uncertainty_score":0.00238806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198919720850775,"score_gpt":0.2643943098952301,"score_spread":0.2445023378101525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}