{"id":"W4214625910","doi":"10.1016/j.scr.2022.102726","title":"Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec; Université du Québec à Chicoutimi","funders":"Fonds de Recherche du Québec - Santé; Fondation du Grand défi Pierre Lavoie; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois; Rare Disease Foundation; Université du Québec à Chicoutimi","keywords":"Epidermolysis bullosa simplex; Induced pluripotent stem cell; Biology; Keratin 5; Sendai virus; Germline; Mutation; Keratin; Keratin 14; Germ layer; Karyotype; Epidermolysis bullosa; Genetics; Embryonic stem cell; Gene; Chromosome; Transgene; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003737926,0.000424003,0.0004253046,0.0007618683,0.0005800823,0.000575661,0.0004141532,0.0009120239,0.004335156],"category_scores_gemma":[0.0007290408,0.0002495764,0.0006576392,0.0005036339,0.0003951928,0.0002151627,0.0005545758,0.0009700975,0.0008041725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003326972,"about_ca_system_score_gemma":0.0003399744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200706,"about_ca_topic_score_gemma":0.001036515,"domain_scores_codex":[0.999736,0.00003024674,0.00005730497,0.00005198763,0.00008288094,0.00004154257],"domain_scores_gemma":[0.9997763,0.00005740842,0.00002236387,0.00004153632,0.00003540789,0.00006690425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007103112,0.0004965245,0.02057655,0.0001811168,0.0001088232,0.01171289,0.001466433,0.0008681867,0.9132228,0.002675947,0.002053592,0.04592678],"study_design_scores_gemma":[0.001496348,0.003930614,0.07612644,0.0001972589,0.0005175668,0.1013596,0.001260623,0.00756842,0.7515455,0.001793984,0.0539889,0.0002146789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791769,0.0009059408,0.01174015,0.0004341863,0.0001197997,0.0007718079,0.002281798,0.0002026432,0.004366784],"genre_scores_gemma":[0.9752611,0.0008369838,0.01480721,0.000461681,0.00003574554,0.000596688,0.004919274,0.00006050775,0.003020948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004335156,"threshold_uncertainty_score":0.01450258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07478755429507601,"score_gpt":0.3038273211623204,"score_spread":0.2290397668672444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}