{"id":"W4214625910","doi":"10.1016/j.scr.2022.102726","title":"Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec; Université du Québec à Chicoutimi","funders":"Fonds de Recherche du Québec - Santé; Fondation du Grand défi Pierre Lavoie; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois; Rare Disease Foundation; Université du Québec à Chicoutimi","keywords":"Epidermolysis bullosa simplex; Induced pluripotent stem cell; Biology; Keratin 5; Sendai virus; Germline; Mutation; Keratin; Keratin 14; Germ layer; Karyotype; Epidermolysis bullosa; Genetics; Embryonic stem cell; Gene; Chromosome; Transgene; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009948207,0.0002777457,0.0003470059,0.0002824552,0.0006886598,0.00006284041,0.0005254471,0.0002222315,0.0001877171],"category_scores_gemma":[0.00002562562,0.0002477817,0.0001182922,0.0005339205,0.00031758,0.00001247002,0.0008435284,0.0005596091,0.00001698552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007011521,"about_ca_system_score_gemma":0.0003286378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997913,"about_ca_topic_score_gemma":0.000508474,"domain_scores_codex":[0.9961096,0.0007708509,0.0004649335,0.0009050351,0.001072902,0.0006766725],"domain_scores_gemma":[0.997976,0.0001738191,0.000175838,0.0008099989,0.0006430871,0.0002212803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004810248,0.0005163814,0.06425273,0.00008172847,0.000172642,0.00006368404,0.0002466114,0.0002276054,0.9153288,0.00002917692,0.0005415509,0.01805806],"study_design_scores_gemma":[0.00369613,0.003223878,0.01686513,0.00002061828,0.00008355047,0.00002524913,0.001976442,0.001926975,0.9686128,0.0002121362,0.002741816,0.0006152492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954901,0.001996078,0.0005197895,0.000136071,0.00009988963,0.0009496561,0.000353774,0.00001350944,0.0004410897],"genre_scores_gemma":[0.9966377,0.0001200692,0.0002071128,0.00002088499,0.0001657514,0.0002644059,0.001591366,0.00005545045,0.0009372324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05328402,"threshold_uncertainty_score":0.9999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07478755429507601,"score_gpt":0.3038273211623204,"score_spread":0.2290397668672444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}