{"id":"W4214635433","doi":"10.3389/fmolb.2022.827638","title":"Human Sulfotransferase Assays With PAPS Production in situ","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Freie Universität Berlin; World Anti-Doping Agency; Deutsche Forschungsgemeinschaft","keywords":"Sulfotransferase; Chemistry; Yeast; Biotransformation; Recombinant DNA; Cofactor; Sulfate; Biochemistry; Enzyme; Metabolism; Organic chemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007065712,0.00108323,0.0003405214,0.0003352331,0.0001525056,0.0003082317,0.0002995169,0.0004537578,0.001382046],"category_scores_gemma":[0.0004818203,0.0003277136,0.0004382676,0.0004398876,0.0002534218,0.0002504546,0.0004213441,0.0008631484,0.001031817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931929,"about_ca_system_score_gemma":0.0002515707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003259264,"about_ca_topic_score_gemma":0.0006196172,"domain_scores_codex":[0.9993147,0.0002419782,0.00006193286,0.000141026,0.0001841763,0.00005617302],"domain_scores_gemma":[0.9996823,0.0000705897,0.00008240424,0.00006407552,0.00007753989,0.00002312734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005264736,0.00001745361,0.0000836066,0.00004334261,0.000007623376,0.00002048121,0.00001947808,0.00007305857,0.9981488,0.00005250321,0.00002999525,0.001451144],"study_design_scores_gemma":[0.000003769975,0.0001288564,0.0001812338,0.000002730199,0.00001122627,0.00006904454,0.000005469094,0.0002468254,0.9977798,0.0000212097,0.001546882,0.000002950895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6684008,0.003517339,0.3191571,0.0002478899,0.0001609787,0.0006417616,0.001754753,0.001144518,0.004974869],"genre_scores_gemma":[0.7928425,0.005063131,0.1800303,0.0001294305,0.00007582625,0.0005476861,0.007267542,0.0003258577,0.01371782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382046,"threshold_uncertainty_score":0.004623413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005103120235532511,"score_gpt":0.208988279874355,"score_spread":0.2038851596388225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}