{"id":"W4214636167","doi":"10.1101/2022.02.24.481870","title":"ProbeTools: Designing hybridization probes for targeted genomic sequencing of diverse and hypervariable viral taxa","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Government of British Columbia; Simon Fraser University; Ministry of Health; University of British Columbia","funders":"Genome British Columbia; Canadian Food Inspection Agency; Canarie","keywords":"In silico; Biology; Subtyping; Computational biology; Genome; Hypervariable region; Genetics; DNA sequencing; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001230774,0.001207825,0.0006307061,0.0009122786,0.0003469111,0.0006841287,0.0006626968,0.00101385,0.004032501],"category_scores_gemma":[0.001952165,0.0007596455,0.0007830521,0.0005578979,0.0005809242,0.000690127,0.0007813925,0.0009829529,0.001787279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004955957,"about_ca_system_score_gemma":0.0004178829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000398327,"about_ca_topic_score_gemma":0.0008146887,"domain_scores_codex":[0.9988678,0.0002796986,0.00006245189,0.0003761075,0.0002739175,0.0001402321],"domain_scores_gemma":[0.9991593,0.0004428229,0.0001363618,0.00007747234,0.0001227476,0.00006120693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001104845,0.00002345437,0.000400389,0.000125005,0.00001530372,0.00004149855,0.00006827978,0.001373121,0.9871847,0.0003357184,0.00036288,0.009959115],"study_design_scores_gemma":[0.00001758009,0.0002196819,0.0006632236,0.00001404839,0.00002203992,0.0001072314,0.00004373567,0.009020392,0.983276,0.0002134341,0.006373651,0.00002886999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2366912,0.0007631676,0.749322,0.000262535,0.0000946437,0.0006698835,0.001901107,0.007736832,0.002558604],"genre_scores_gemma":[0.2448993,0.0006168618,0.7428073,0.0005229325,0.00002766577,0.001409137,0.003541343,0.001134057,0.005041385],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004032501,"threshold_uncertainty_score":0.01349002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05736714419477477,"score_gpt":0.2855745443559851,"score_spread":0.2282074001612103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}