{"id":"W4214645702","doi":"10.1073/pnas.2121478119","title":"Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Israel Science Foundation; Israel Cancer Research Fund","keywords":"Anaphase-promoting complex; Cell biology; Spindle checkpoint; Mad2; Mitosis; Mitotic exit; Biology; Ubiquitin ligase; CDC20; Anaphase; Cell cycle checkpoint; Securin; Chemistry; Ubiquitin; Spindle apparatus; Cell cycle; Biochemistry; Cell division; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283791,0.0002765718,0.0001420716,0.0001736988,0.0002426223,0.000430168,0.0001957548,0.0002703201,0.001184925],"category_scores_gemma":[0.0001114093,0.0001410582,0.0002045789,0.00008071994,0.0001421292,0.0002386161,0.0001614046,0.0002909664,0.0004838769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007231458,"about_ca_system_score_gemma":0.0002058335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088945,"about_ca_topic_score_gemma":0.002197458,"domain_scores_codex":[0.9998977,0.00001293965,0.000007896021,0.00002754834,0.00002288973,0.00003105329],"domain_scores_gemma":[0.9999505,0.000004418109,0.00001285546,0.000005489441,0.000004686492,0.00002199545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066421,0.00001757062,0.0005803534,0.00003540086,0.000009122288,0.000097727,0.000009173141,0.00006097732,0.9976643,0.0001987584,0.00004288936,0.001176891],"study_design_scores_gemma":[0.00001231923,0.0001102009,0.01903605,0.00001189106,0.00001766661,0.0003725226,0.00002879308,0.001753037,0.9762449,0.00004535913,0.002362536,0.000004685876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919357,0.004493368,0.001521337,0.0001312817,0.00002443074,0.000008198075,0.0001331422,0.00006473646,0.001687671],"genre_scores_gemma":[0.9962839,0.0004636887,0.0006710808,0.0000324377,0.000004523771,0.000003522085,0.0002630918,0.000005770908,0.00227193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184925,"threshold_uncertainty_score":0.005246758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941175197059943,"score_gpt":0.2754375225568306,"score_spread":0.2560257705862312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}