{"id":"W4214658927","doi":"10.3390/ph15030283","title":"Structure–Activity Relationship of N-Phenylthieno[2,3-b]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Moiety; MTT assay; Stereochemistry; Pyridine; Docking (animal); IC50; Ring (chemistry); In vitro; Biochemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008698832,0.0001775773,0.0001850442,0.00004886027,0.0003809028,0.00001857595,0.0001863001,0.00006156413,0.00002879722],"category_scores_gemma":[0.0005776087,0.0001207585,0.00008658412,0.0002241805,0.0001984103,0.00001493199,0.00009767157,0.0003174182,4.02183e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003891826,"about_ca_system_score_gemma":0.00003984706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001853066,"about_ca_topic_score_gemma":0.000004032583,"domain_scores_codex":[0.9981188,0.0007720436,0.0002698018,0.0002741411,0.0003432751,0.0002219601],"domain_scores_gemma":[0.9987621,0.0006947089,0.0002055623,0.0002436248,0.0000461025,0.00004792658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004362183,0.00002640325,0.0158263,0.00004763188,0.00008234014,4.288119e-7,0.0002475011,0.002231299,0.9796255,0.0007868127,0.00001739248,0.0006721754],"study_design_scores_gemma":[0.0007138684,0.0004059994,0.01423151,0.00002405788,0.00006412419,0.000008199328,0.00006306502,0.0008387874,0.9830501,0.0002601788,0.0002239346,0.0001161664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997692,0.0005007837,0.000473857,0.0004099829,0.000108417,0.0006145486,0.00002252861,0.0000130697,0.0001648389],"genre_scores_gemma":[0.999677,0.00001147478,0.00006155166,0.00008163365,0.00006295853,0.0000527559,0.00001866484,0.00002199939,0.00001194392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003424609,"threshold_uncertainty_score":0.4924389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388481419419148,"score_gpt":0.3091695780777465,"score_spread":0.2852847638835551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}