{"id":"W4214658927","doi":"10.3390/ph15030283","title":"Structure–Activity Relationship of N-Phenylthieno[2,3-b]pyridine-2-carboxamide Derivatives Designed as Forkhead Box M1 Inhibitors: The Effect of Electron-Withdrawing and Donating Substituents on the Phenyl Ring","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Moiety; MTT assay; Stereochemistry; Pyridine; Docking (animal); IC50; Ring (chemistry); In vitro; Biochemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538492,0.0003095784,0.0002615387,0.0001535128,0.00007674599,0.0001123744,0.0002099499,0.00015293,0.0009954614],"category_scores_gemma":[0.0001394329,0.00009951922,0.00015965,0.000149164,0.0001065196,0.0001141297,0.00007536807,0.0002159989,0.0001723423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587886,"about_ca_system_score_gemma":0.0001666245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008232006,"about_ca_topic_score_gemma":0.001460337,"domain_scores_codex":[0.9999582,0.00001008393,0.000003634723,0.000006852168,0.000009434383,0.00001187257],"domain_scores_gemma":[0.9999305,0.00001433496,0.00002059447,0.000005028682,0.00001119897,0.00001830684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006937837,0.0003033013,0.0008165627,0.0001582246,0.00003571155,0.0001300498,0.0000358572,0.002584858,0.9885406,0.00009764115,0.00009336312,0.006510081],"study_design_scores_gemma":[0.0002997014,0.01003868,0.01311427,0.00001786329,0.0001576064,0.0003556151,0.0000293772,0.005474366,0.966768,0.00004408685,0.003675168,0.00002530232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963253,0.002105537,0.0004946763,0.00002807349,0.00001100868,0.00003032827,0.0002070508,0.0000204113,0.0007776007],"genre_scores_gemma":[0.9950122,0.002080942,0.001328672,0.00002449415,0.000007698574,0.00003861255,0.0004535545,0.00000436721,0.001049429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009954614,"threshold_uncertainty_score":0.003330112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388481419419148,"score_gpt":0.3091695780777465,"score_spread":0.2852847638835551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}