{"id":"W4214686760","doi":"10.1016/s0140-6736(21)02225-x","title":"Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial","year":2022,"lang":"en","type":"letter","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; University of Alberta; Ottawa Allergy Research Corporation; University of Ottawa","funders":"CSL Behring","keywords":"Hereditary angioedema; Double blind; Medicine; Placebo; Angioedema; Monoclonal antibody; Prophylactic treatment; Monoclonal; Internal medicine; Antibody; Dermatology; Gastroenterology; Immunology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005777209,0.0009061972,0.003220261,0.0003825888,0.0004016719,0.0001627216,0.0005026416,0.0004954675,0.0003519998],"category_scores_gemma":[0.0002456688,0.0005751791,0.0007856524,0.0004196097,0.0002649788,0.000445423,0.00009499865,0.001242461,0.000004221256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001932147,"about_ca_system_score_gemma":0.0005656543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000183701,"about_ca_topic_score_gemma":0.000008620418,"domain_scores_codex":[0.9949197,0.0004515666,0.001320734,0.0009621579,0.001406271,0.0009395685],"domain_scores_gemma":[0.995479,0.001120148,0.001401171,0.001365374,0.0004425058,0.000191749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9464351,0.002284927,0.0007367763,0.0006579301,0.001051363,0.0001754307,0.0004595479,0.0000940035,0.0005513743,0.000004537771,0.04721025,0.0003387702],"study_design_scores_gemma":[0.9474244,0.007412138,0.0003520492,0.0002453658,0.001794242,0.00004897999,0.00004882769,0.0006132793,0.000957816,0.000009606017,0.0403819,0.0007113799],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596071,0.0003572493,0.00007846794,0.01877447,0.001423019,0.01726788,0.002291348,0.0001582359,0.00004223303],"genre_scores_gemma":[0.9424779,0.00002748345,0.0005646946,0.02461327,0.01365514,0.002197312,0.01526219,0.0003326047,0.0008694457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01712923,"threshold_uncertainty_score":0.99967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06239459912343721,"score_gpt":0.3196806332779118,"score_spread":0.2572860341544746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}