{"id":"W4214686760","doi":"10.1016/s0140-6736(21)02225-x","title":"Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial","year":2022,"lang":"en","type":"letter","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; University of Alberta; Ottawa Allergy Research Corporation; University of Ottawa","funders":"CSL Behring","keywords":"Hereditary angioedema; Double blind; Medicine; Placebo; Angioedema; Monoclonal antibody; Prophylactic treatment; Monoclonal; Internal medicine; Antibody; Dermatology; Gastroenterology; Immunology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001349563,0.001286404,0.002322693,0.0002518914,0.0003357708,0.0008487877,0.0007202987,0.003285068,0.006646469],"category_scores_gemma":[0.002034029,0.0004330096,0.001281459,0.000287825,0.0006642583,0.000688863,0.0001952401,0.003171015,0.001126229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007164147,"about_ca_system_score_gemma":0.0007209971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009625307,"about_ca_topic_score_gemma":0.002207499,"domain_scores_codex":[0.9995766,0.0002407804,0.00002671042,0.00005910023,0.00004178167,0.0000550177],"domain_scores_gemma":[0.999227,0.0004008198,0.0001089288,0.00002921642,0.00004696973,0.000187119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9384478,0.002006115,0.0009197827,0.002236405,0.002156755,0.0002635302,0.00004890889,0.0002131472,0.003266631,0.000330475,0.01255163,0.03755872],"study_design_scores_gemma":[0.9792536,0.01417237,0.001774775,0.00009828949,0.0006566711,0.00008870676,0.0000174585,0.0002543325,0.0002595079,0.0002779431,0.003133127,0.00001325713],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8058655,0.1078403,0.002380353,0.03375789,0.01917508,0.004525628,0.005045353,0.0005845756,0.02082543],"genre_scores_gemma":[0.9220787,0.02034384,0.002293268,0.03130985,0.005139742,0.002980816,0.002047552,0.000053571,0.01375258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006646469,"threshold_uncertainty_score":0.02223468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06239459912343721,"score_gpt":0.3196806332779118,"score_spread":0.2572860341544746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}