{"id":"W4214694674","doi":"10.1053/j.gastro.2022.02.033","title":"Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Sandoz; Johnson and Johnson; Genentech; Active Biotech; Toray Industries; Shire; Kissei; Otsuka America; UCB; Taiho Pharmaceutical; Eli Lilly and Company; Boehringer Ingelheim España; Celgene; Gilead Sciences; AstraZeneca España; Medtronic; Takeda Pharmaceutical Company; Amgen; Schering-Plough; GlaxoSmithKline España; AbbVie; Astellas Pharma US; Kaken Pharmaceutical; National Institute of Diabetes and Digestive and Kidney Diseases; Kyowa Hakko Kirin; Kyorin Pharmaceutical; Sanofi; Merck; Allergan; Seres Therapeutics; Roche España; Nippon Kayaku; Pfizer; Bristol-Myers Squibb","keywords":"Ulcerative colitis; Dosing; Medicine; Adalimumab; Internal medicine; Maintenance therapy; Chemotherapy; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003412808,0.0008800544,0.002095741,0.0003577941,0.0003228478,0.0009838514,0.0007083113,0.001409426,0.005454836],"category_scores_gemma":[0.002090887,0.0003768561,0.002156325,0.0002808783,0.0006794772,0.0009669261,0.0004813494,0.002523677,0.0004631522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004112896,"about_ca_system_score_gemma":0.0005682327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003444583,"about_ca_topic_score_gemma":0.001148481,"domain_scores_codex":[0.9986792,0.000889139,0.00008531635,0.0001464209,0.00009318625,0.0001066401],"domain_scores_gemma":[0.9984866,0.000575027,0.0003798564,0.0001502922,0.00007016686,0.0003380456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9781918,0.004039441,0.001048772,0.0006636638,0.001195934,0.00003168961,0.00005503062,0.0003081845,0.001836337,0.0001275153,0.0007668759,0.01173478],"study_design_scores_gemma":[0.9188699,0.07117853,0.005623313,0.00009063294,0.001661261,0.00008435304,0.00002467121,0.0004709413,0.0005783903,0.0001014844,0.001297388,0.00001926259],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845109,0.008453599,0.0004528076,0.0006279452,0.000231461,0.001130945,0.0009330761,0.00009441951,0.003564732],"genre_scores_gemma":[0.9892384,0.002626498,0.001621532,0.0009645727,0.0004360921,0.001315919,0.001371865,0.00001744386,0.002407616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005454836,"threshold_uncertainty_score":0.01824826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368106343607685,"score_gpt":0.2539746493150556,"score_spread":0.2402935858789788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}