{"id":"W4214694674","doi":"10.1053/j.gastro.2022.02.033","title":"Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Sandoz; Johnson and Johnson; Genentech; Active Biotech; Toray Industries; Shire; Kissei; Otsuka America; UCB; Taiho Pharmaceutical; Eli Lilly and Company; Boehringer Ingelheim España; Celgene; Gilead Sciences; AstraZeneca España; Medtronic; Takeda Pharmaceutical Company; Amgen; Schering-Plough; GlaxoSmithKline España; AbbVie; Astellas Pharma US; Kaken Pharmaceutical; National Institute of Diabetes and Digestive and Kidney Diseases; Kyowa Hakko Kirin; Kyorin Pharmaceutical; Sanofi; Merck; Allergan; Seres Therapeutics; Roche España; Nippon Kayaku; Pfizer; Bristol-Myers Squibb","keywords":"Ulcerative colitis; Dosing; Medicine; Adalimumab; Internal medicine; Maintenance therapy; Chemotherapy; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640741,0.0001354742,0.0002114499,0.00004046087,0.0001280431,0.000007053293,0.00006618771,0.00005615087,0.00001764493],"category_scores_gemma":[0.00002282795,0.0001340171,0.00007925678,0.00002217393,0.0001055145,0.000003950333,0.00007166533,0.00003484691,2.195876e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008948978,"about_ca_system_score_gemma":0.00005945843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001702044,"about_ca_topic_score_gemma":0.000138802,"domain_scores_codex":[0.9988159,0.00022692,0.0002688544,0.0003403219,0.00008383022,0.0002641923],"domain_scores_gemma":[0.9994491,0.00001052469,0.0001863457,0.0002151181,0.00007907879,0.00005986729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9744522,0.0002869742,0.001754902,0.00002568677,0.0002592567,0.00003664285,0.0002671531,0.0002065242,0.0152344,0.0002108643,0.006635207,0.0006302127],"study_design_scores_gemma":[0.5255141,0.1150619,0.162369,0.00003881361,0.0004183466,0.0002229887,0.0008767935,0.0001433559,0.02141673,0.00065101,0.1727187,0.0005682909],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996674,0.00003556149,0.0002862669,0.0006683298,0.0004129779,0.0007002644,0.00115934,0.00000869675,0.00005455299],"genre_scores_gemma":[0.9979105,0.00003571162,0.0004087668,0.0002191438,0.0002211956,0.0003404349,0.0003592833,0.0000173758,0.0004876096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.448938,"threshold_uncertainty_score":0.5465057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368106343607685,"score_gpt":0.2539746493150556,"score_spread":0.2402935858789788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}