{"id":"W4214695385","doi":"10.1016/j.celrep.2022.110442","title":"Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genome Center, University of California, Davis; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Intellectual and Developmental Disabilities Research Center; University of California, Davis; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Iowa","keywords":"Differentially methylated regions; Placenta; DNA methylation; Fetus; Biology; Epigenetics; Methylation; Genetics; Gene; Pregnancy; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002403441,0.000103097,0.000108259,0.00005532262,0.00006191448,0.000008857189,0.00005135403,0.00005649934,0.00003198972],"category_scores_gemma":[0.0000466839,0.0001131158,0.00003511224,0.00006727778,0.00002261973,0.00000555368,0.0002139822,0.00008194767,1.54212e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001835523,"about_ca_system_score_gemma":0.00008992607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001776807,"about_ca_topic_score_gemma":0.00002915443,"domain_scores_codex":[0.999025,0.00005819554,0.0003001391,0.0003270096,0.0001622888,0.0001272974],"domain_scores_gemma":[0.9995655,0.000008106766,0.0001698887,0.0001907592,0.00002660821,0.00003908562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004390704,0.0001090018,0.03048285,0.00003815929,0.000005839418,0.00001140327,0.0002711705,0.00649156,0.9609029,0.000001957168,0.00006744272,0.001573845],"study_design_scores_gemma":[0.0004758346,0.0001927074,0.005500088,0.000004283319,0.000005851653,0.00001330864,0.0001710436,0.005423611,0.9871079,0.00007774548,0.0008592298,0.000168392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978776,0.0007417845,0.0004201771,0.00002735849,0.00005195474,0.0002917206,0.00006816927,0.000005404787,0.000515841],"genre_scores_gemma":[0.9968609,0.0000382808,0.0007030229,0.00002321498,0.00001173053,0.00005940311,0.0006508895,0.00001844523,0.001634138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02620503,"threshold_uncertainty_score":0.4612729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009691181634281905,"score_gpt":0.2241292098642752,"score_spread":0.2144380282299933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}