{"id":"W4214695385","doi":"10.1016/j.celrep.2022.110442","title":"Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genome Center, University of California, Davis; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Intellectual and Developmental Disabilities Research Center; University of California, Davis; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Iowa","keywords":"Differentially methylated regions; Placenta; DNA methylation; Fetus; Biology; Epigenetics; Methylation; Genetics; Gene; Pregnancy; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792582,0.0003866566,0.0002755249,0.001158081,0.000194487,0.0003376781,0.0001877398,0.0002806152,0.002299922],"category_scores_gemma":[0.0002266387,0.0003431925,0.000327334,0.0003305039,0.0004202574,0.0001718435,0.0004266164,0.0006519781,0.0002325123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004389633,"about_ca_system_score_gemma":0.0002902895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002038931,"about_ca_topic_score_gemma":0.002900415,"domain_scores_codex":[0.999619,0.00004414798,0.00002148968,0.0001357638,0.0001121797,0.00006741465],"domain_scores_gemma":[0.9997835,0.00001978994,0.00008315636,0.00003082574,0.00002177122,0.0000609726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000445217,0.00002388994,0.002372493,0.00002664542,0.0000238925,0.0001385958,0.00005019149,0.00004424604,0.9943824,0.0001464471,0.00004932939,0.002296566],"study_design_scores_gemma":[0.0000401267,0.0005007605,0.1090025,0.00002960535,0.000142711,0.00286719,0.000209218,0.0007312907,0.8811345,0.0003100849,0.005013913,0.00001814658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850604,0.001941958,0.008582067,0.0001826774,0.00003874189,0.00003006333,0.001824354,0.0001943481,0.002145406],"genre_scores_gemma":[0.9845985,0.001275974,0.005751413,0.0001229874,0.000009396622,0.00008742179,0.001804089,0.00009461478,0.006255573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002299922,"threshold_uncertainty_score":0.007694066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009691181634281905,"score_gpt":0.2241292098642752,"score_spread":0.2144380282299933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}