{"id":"W4214698582","doi":"10.1038/s41398-022-01850-z","title":"Increased retention of tau PET ligand [18F]-AV1451 in Alzheimer’s Disease Psychosis","year":2022,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neuropathology; Psychosis; Neuroimaging; Positron emission tomography; Psychology; Alzheimer's Disease Neuroimaging Initiative; Disease; Biomarker; Dementia; Schizophrenia (object-oriented programming); Alzheimer's disease; Cognitive decline; Internal medicine; Medicine; Neuroscience; Oncology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002107989,0.0001719795,0.0002541484,0.0003094763,0.0001350032,0.000007573242,0.0001069548,0.00002328763,0.00137817],"category_scores_gemma":[0.000008523658,0.0001658467,0.0002956634,0.00049767,0.00007019362,0.0001050605,0.00001845463,0.0002548116,0.00002352475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004736661,"about_ca_system_score_gemma":0.000696071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002413347,"about_ca_topic_score_gemma":0.00004326989,"domain_scores_codex":[0.9980423,0.0001263417,0.0003933534,0.0003424627,0.0008315121,0.0002640531],"domain_scores_gemma":[0.9991678,0.00004652285,0.00009089028,0.0002830645,0.00006811742,0.0003436154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004907831,0.00276214,0.9854817,0.00007384219,0.002550846,0.00008360571,0.0000593441,0.0002006326,0.00006433816,0.001408006,0.001872413,0.0005353261],"study_design_scores_gemma":[0.005485502,0.0003316361,0.9863525,0.00006756477,0.0008066934,0.00002846366,0.00007063799,0.0007196285,0.00001781804,0.005823101,0.0001493595,0.0001470844],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772452,0.01560965,0.00001880678,0.00422762,0.0001909431,0.0007946792,0.0007033973,0.0000384844,0.001171293],"genre_scores_gemma":[0.9975451,0.00006431507,0.000706289,0.0001525551,0.0000866033,0.0001716112,0.001228286,0.00002894345,0.00001625999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02030001,"threshold_uncertainty_score":0.9995347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03428337088878099,"score_gpt":0.3211080499126304,"score_spread":0.2868246790238494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}