{"id":"W4214700079","doi":"10.21203/rs.3.rs-1319240/v1","title":"Evaluating the Potential of Third Generation Metagenomic Sequencing for the Detection of BRD Pathogens and Genetic Determinants of Resistance in Chronically ill Feedlot Cattle","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Beef Cattle Research Council","keywords":"Biology; Metagenomics; Bovine respiratory disease; Antibiotic resistance; Microbiology; Pasteurella multocida; Drug resistance; Antimicrobial; Virology; Antibiotics; Gene; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001022012,0.0005206676,0.0006320601,0.001019988,0.000359708,0.001046018,0.0003577457,0.0008198277,0.0004272097],"category_scores_gemma":[0.001144201,0.0002492658,0.0005075182,0.0005600106,0.0002921347,0.0003086045,0.0003947402,0.0003372964,0.0001528247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005391072,"about_ca_system_score_gemma":0.0003230938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002367338,"about_ca_topic_score_gemma":0.004765146,"domain_scores_codex":[0.9991087,0.0002195155,0.0000456094,0.0002314181,0.0002734044,0.0001212769],"domain_scores_gemma":[0.9992285,0.0002557232,0.000157411,0.00003971348,0.0002343195,0.00008446167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001194208,0.0002299196,0.2410335,0.0003419571,0.00032366,0.0002259569,0.0004795699,0.002203588,0.7338715,0.0001219227,0.0002224266,0.01975175],"study_design_scores_gemma":[0.00004428249,0.002715432,0.7447697,0.0001845579,0.0006957541,0.00132757,0.001871371,0.03339647,0.2104477,0.0004000657,0.004059879,0.00008717665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937971,0.0006785361,0.003392037,0.00009468643,0.00001661221,0.00003907209,0.001642096,0.00003384659,0.0003061845],"genre_scores_gemma":[0.9870939,0.0003334506,0.01002277,0.0001487586,0.00001450088,0.00004937834,0.002002853,0.00001390918,0.0003205744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002367338,"threshold_uncertainty_score":0.005404949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1088718157569585,"score_gpt":0.4110118352234341,"score_spread":0.3021400194664756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}