{"id":"W4214700498","doi":"10.1007/s00392-022-01992-6","title":"Gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and cardiovascular risk in patients with suspected functionally relevant coronary artery disease (fCAD)","year":2022,"lang":"en","type":"article","venue":"Clinical Research in Cardiology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Kommission für Technologie und Innovation; Singulex; Schweizerische Herzstiftung; Universität Basel; Roche; European Commission; Abbott Laboratories","keywords":"Trimethylamine N-oxide; Medicine; Carnitine; Internal medicine; Choline; Coronary artery disease; Betaine; Cardiology; Acetylcarnitine; Area under the curve; Myocardial infarction; Trimethylamine; Gastroenterology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000300427,0.0003165905,0.0003984498,0.000371888,0.000286984,0.0004335106,0.0001573659,0.0004957455,0.0009313803],"category_scores_gemma":[0.001177595,0.0001866266,0.0002642517,0.0003736257,0.0001733404,0.0002052453,0.0003237419,0.0004985974,0.0001347617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160672,"about_ca_system_score_gemma":0.0001542589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001852117,"about_ca_topic_score_gemma":0.002418089,"domain_scores_codex":[0.9998665,0.00004052389,0.00001533653,0.00003423452,0.0000205794,0.00002270101],"domain_scores_gemma":[0.9995837,0.00008372694,0.0001742759,0.00002487197,0.00003801028,0.00009543688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005391731,0.0000377365,0.9976436,0.00001416072,0.00005254129,0.00007591821,0.00002127363,0.00001892075,0.0004800188,0.000005421484,0.00003588161,0.001075222],"study_design_scores_gemma":[0.00001342023,0.0002398232,0.9990268,0.000007029489,0.00005281573,0.000261125,0.00005411196,0.0001957587,0.00007259275,0.00001695276,0.0000572877,0.00000230569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987606,0.0009196814,0.00003928232,0.00003694455,0.000005195015,0.000003390075,0.00009325136,0.000002252981,0.0001394399],"genre_scores_gemma":[0.9996008,0.0001516981,0.0000702031,0.00001693115,0.000007085374,0.000002794515,0.00009906258,5.932867e-7,0.00005090408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852117,"threshold_uncertainty_score":0.003682613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03954787751903991,"score_gpt":0.3436003569346448,"score_spread":0.3040524794156049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}