{"id":"W4214706986","doi":"10.3389/froh.2022.847914","title":"Eriodictyol Suppresses Porphyromonas gingivalis-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophages","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oral Health","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Universitetet i Oslo; Université Laval","keywords":"Porphyromonas gingivalis; Eriodictyol; Reactive oxygen species; Periodontal pathogen; Chemistry; Matrix metalloproteinase; Macrophage; Periodontitis; Aggregatibacter actinomycetemcomitans; NALP3; Microbiology; Immunology; Inflammasome; Biology; Biochemistry; Medicine; Antioxidant; In vitro; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684494,0.0002912118,0.0003283469,0.0001771183,0.0001175218,0.0001477335,0.0001344067,0.0002430676,0.0007033317],"category_scores_gemma":[0.00009990107,0.0001058821,0.0002259575,0.00008785827,0.0001956846,0.000149866,0.0001625243,0.0004624081,0.000130547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001046504,"about_ca_system_score_gemma":0.0002246296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004112925,"about_ca_topic_score_gemma":0.0007301084,"domain_scores_codex":[0.9999294,0.00001902583,0.00000798462,0.000008033412,0.00001158053,0.00002390456],"domain_scores_gemma":[0.9999384,0.00001095773,0.00001934667,0.000006271825,0.000008853196,0.00001626871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012713,0.0002983692,0.0001337993,0.0001579839,0.000008162021,0.00008358786,0.00003127438,0.00006483003,0.9950494,0.00001969586,0.00005991699,0.003080175],"study_design_scores_gemma":[0.0004130822,0.008933832,0.01061182,0.00004631313,0.00006980861,0.0003689538,0.0001771712,0.0009243945,0.9748198,0.00005697781,0.003567579,0.00001028886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954636,0.003243217,0.0004367879,0.0001023175,0.00002591433,0.00003513157,0.00007422998,0.00002765425,0.0005913127],"genre_scores_gemma":[0.9944918,0.002652879,0.0008690775,0.00009874847,0.00002032982,0.00005115719,0.0001441473,0.000007442784,0.001664462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007033317,"threshold_uncertainty_score":0.002352893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996860152786283,"score_gpt":0.2918577006960741,"score_spread":0.2718890991682113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}