{"id":"W4214713665","doi":"10.1016/j.celrep.2022.110453","title":"SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Illinois Humanities Council; National Cancer Institute; National Institutes of Health; Children's Health Research Institute","keywords":"SDHB; Carcinogenesis; Cancer research; Pheochromocytoma; Succinate dehydrogenase; Neurofibromin 1; Paraganglioma; Phenotype; DNA methylation; Biology; Chemistry; Gene; Gene expression; Cell biology; Mitochondrion; Mutation; Biochemistry; Endocrinology; Germline mutation; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003705386,0.0002330053,0.0002726256,0.00007374728,0.0003864997,0.00004111508,0.00008487314,0.0001295012,0.00009360746],"category_scores_gemma":[0.0000669024,0.000249241,0.0001543253,0.0001195786,0.00005747152,0.000007497484,0.0002632072,0.00011585,0.000001398099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004576844,"about_ca_system_score_gemma":0.0001918641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006554252,"about_ca_topic_score_gemma":0.00004549867,"domain_scores_codex":[0.9982262,0.00005367516,0.0004094425,0.0006868358,0.0002581177,0.000365745],"domain_scores_gemma":[0.9988427,0.00001779768,0.0003602432,0.0005082078,0.0001333963,0.0001376099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007335171,0.0008509839,0.005760306,0.0003727629,0.0001772627,0.001459233,0.0007560848,0.003742688,0.9395039,0.00007661669,0.03297586,0.01359081],"study_design_scores_gemma":[0.0009603327,0.00034842,0.008237369,0.00001011215,0.00009907228,0.002182437,0.0003510316,0.0002200213,0.3924683,0.00009529231,0.5945482,0.0004794877],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895961,0.006069338,0.0004458967,0.00008509092,0.002695116,0.0005258548,0.00009466414,0.00003062502,0.0004573373],"genre_scores_gemma":[0.9927822,0.0002507247,0.0001597665,0.0002186155,0.0009466126,0.0001776498,0.0003672179,0.00004604861,0.005051115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5615723,"threshold_uncertainty_score":0.999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633901803708953,"score_gpt":0.2565541696611713,"score_spread":0.2402151516240818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}