{"id":"W4214723813","doi":"10.1101/gad.349039.121","title":"Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states","year":2022,"lang":"en","type":"article","venue":"Genes & Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Biofyzikální Ústav, Akademie Věd České Republiky; National Institutes of Health; Canadian Institutes of Health Research; Grantová Agentura České Republiky","keywords":"Biology; Rap1; Telomere; Cell biology; Regulation of gene expression; Gene; Histone; Histone acetyltransferase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172835,0.0002985086,0.0001958875,0.0002649889,0.0001845954,0.0004082684,0.0002665419,0.0002753366,0.0012255],"category_scores_gemma":[0.0001275741,0.0001626556,0.0001848343,0.0001155417,0.0001952466,0.0002654833,0.0004825217,0.0004804147,0.0006560464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217758,"about_ca_system_score_gemma":0.0001158544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001500388,"about_ca_topic_score_gemma":0.0002636007,"domain_scores_codex":[0.9998493,0.00001717222,0.00001125278,0.00004392341,0.00004201863,0.00003627393],"domain_scores_gemma":[0.9998596,0.00001723075,0.00004794359,0.0000171896,0.00001368372,0.00004441866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002167952,0.000004194254,0.0002096424,0.00001028114,0.00000122284,0.00004223819,0.000009404871,0.00002931391,0.9983801,0.0001045337,0.00001742406,0.001170025],"study_design_scores_gemma":[0.000005770356,0.00006828777,0.01502762,0.000006353338,0.000008649857,0.0004403094,0.00003473047,0.0009753178,0.9811689,0.0001376519,0.002120489,0.000006123281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903749,0.001022622,0.005727808,0.00005520135,0.00001225974,0.00001348099,0.0004009656,0.000192359,0.002200349],"genre_scores_gemma":[0.9957271,0.0003483528,0.00152316,0.00003283687,0.000003805682,0.00001661857,0.0004469157,0.0000413066,0.001860005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0012255,"threshold_uncertainty_score":0.004099727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004674864617471273,"score_gpt":0.2201621319810095,"score_spread":0.2154872673635382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}