{"id":"W4214723813","doi":"10.1101/gad.349039.121","title":"Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states","year":2022,"lang":"en","type":"article","venue":"Genes & Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Biofyzikální Ústav, Akademie Věd České Republiky; National Institutes of Health; Canadian Institutes of Health Research; Grantová Agentura České Republiky","keywords":"Biology; Rap1; Telomere; Cell biology; Regulation of gene expression; Gene; Histone; Histone acetyltransferase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353609,0.0001525198,0.0001098399,0.00005653022,0.0002741144,0.00001963412,0.00007246686,0.0000371363,0.00003054841],"category_scores_gemma":[0.000001026856,0.0001671356,0.00003589256,0.00006646313,0.00001644063,0.000003013992,0.0001358635,0.00006524177,0.000003165917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003263944,"about_ca_system_score_gemma":0.00003823008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009371449,"about_ca_topic_score_gemma":0.000008053993,"domain_scores_codex":[0.9990727,0.00002896605,0.0001995446,0.0003179351,0.0001503188,0.0002305649],"domain_scores_gemma":[0.9997289,0.000003907683,0.00003793412,0.0001359909,0.00002437039,0.00006895627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007959729,0.00002923281,0.002144173,0.00006219038,0.00009675968,0.000004397607,0.0008004749,0.02425024,0.9525266,0.000001559388,0.0001879641,0.01981684],"study_design_scores_gemma":[0.000953135,0.0001341258,0.0412455,0.000007609504,0.00003662961,0.00002135546,0.0004639347,0.0001826523,0.9023803,0.00003249702,0.05420346,0.0003388275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878541,0.003133616,0.008530957,0.00006974284,0.0001797445,0.0001589636,0.00001384097,0.00002520691,0.00003383277],"genre_scores_gemma":[0.9970593,0.0003540232,0.001447436,0.00006581769,0.0001058964,0.0000684241,0.0004712605,0.00002366582,0.0004041379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0540155,"threshold_uncertainty_score":0.6815593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004674864617471273,"score_gpt":0.2201621319810095,"score_spread":0.2154872673635382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}