{"id":"W4214738129","doi":"10.1101/2022.02.22.481528","title":"The gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Staatssekretariat für Bildung, Forschung und Innovation; Biotechnology and Biological Sciences Research Council; Medical Research Council; Innovative Medicines Initiative; Walloon excellence in life sciences and biotechnology; Waalse Gewest; Innoviris; European Commission; Université de Montréal; Diabetes Fonds; Human Islet Research Network; European Federation of Pharmaceutical Industries and Associations; University of Pennsylvania; Wellcome Trust; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Biology; Transcriptome; Cell type; Alpha cell; Alpha (finance); Type 2 diabetes; Gene; Cell biology; Cell; Gene expression; Endocrinology; Islet; Genetics; Diabetes mellitus; Beta cell; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769593,0.0002310147,0.0002013506,0.0005359465,0.0001575415,0.0004408569,0.00007650763,0.0002342691,0.002190857],"category_scores_gemma":[0.0002414786,0.0001185658,0.0002364086,0.0005965201,0.0002193038,0.0001093976,0.0002180463,0.0002881072,0.0004975804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007905017,"about_ca_system_score_gemma":0.00007459115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001706632,"about_ca_topic_score_gemma":0.000237942,"domain_scores_codex":[0.9997754,0.00003181507,0.00002250064,0.00009148879,0.00004169794,0.00003710513],"domain_scores_gemma":[0.9998438,0.00003031351,0.00005469023,0.00002701972,0.00001815184,0.00002595217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008666958,0.00001865349,0.01303596,0.00006584259,0.00002658744,0.0001571049,0.00007628593,0.00004322891,0.9828424,0.00003720025,0.0001010063,0.002729032],"study_design_scores_gemma":[0.00006491699,0.0007504445,0.7604723,0.00002984147,0.0001163152,0.002989162,0.0004576988,0.000636737,0.2288398,0.0002539112,0.005367973,0.00002091719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993615,0.001221644,0.001531751,0.00006459313,0.00003619092,0.00001782124,0.00266713,0.00003366435,0.0008121144],"genre_scores_gemma":[0.9920418,0.0009109013,0.00175725,0.0001160076,0.00003919406,0.0000577081,0.00377302,0.00002518864,0.001279071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190857,"threshold_uncertainty_score":0.007329166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493212595761493,"score_gpt":0.206570459871521,"score_spread":0.191638333913906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}