{"id":"W4214761517","doi":"10.1681/asn.2021050723","title":"DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute on Minority Health and Health Disparities; National Institutes of Health","keywords":"Cytotoxicity; Cytotoxic T cell; Lipogenesis; Kidney; Lipid droplet; Renal injury","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763897,0.000329963,0.0003830644,0.0002031347,0.0001500182,0.0003624955,0.0002479921,0.0003321676,0.002127673],"category_scores_gemma":[0.0001496211,0.0001577564,0.0003886866,0.0001672005,0.0002174648,0.0001308368,0.0002336352,0.0009267375,0.0004490178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757501,"about_ca_system_score_gemma":0.000212706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007947376,"about_ca_topic_score_gemma":0.00117973,"domain_scores_codex":[0.9998087,0.00002844377,0.00002753003,0.00005014578,0.00004122338,0.00004388437],"domain_scores_gemma":[0.9998165,0.0000333706,0.00004229679,0.00002371594,0.00002179375,0.00006236055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003439942,0.00006153977,0.0001706264,0.00004594125,0.0000105143,0.00003511417,0.00001301507,0.00006073198,0.9984722,0.00003164819,0.00008339666,0.0006713168],"study_design_scores_gemma":[0.0000675105,0.00066643,0.003089356,0.000005353531,0.00002713238,0.0001669845,0.00003132535,0.0006369352,0.9932607,0.00003594457,0.002006219,0.000006163516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927918,0.001515497,0.002600472,0.0002258432,0.0001114632,0.00005625076,0.001083286,0.0002198051,0.001395571],"genre_scores_gemma":[0.9933257,0.0007211544,0.002265905,0.0001619427,0.00001671217,0.00007998008,0.001024676,0.00004826551,0.002355638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002127673,"threshold_uncertainty_score":0.007117808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105410572357284,"score_gpt":0.262322946140956,"score_spread":0.2517818889052276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}