{"id":"W4214761731","doi":"10.1681/asn.2021040491","title":"Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; McMaster University; Population Health Research Institute; Hôpital du Sacré-Cœur de Montréal","funders":"National Cancer Institute; National Institute of Mental Health; Sixth Framework Programme; National Institutes of Health; Chinese Society of Clinical Oncology; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Scottish Government; Schweizerische Herzstiftung; Ministero della Salute; Universität Zürich; Bundesministerium für Bildung und Forschung; NIH Office of the Director; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Medical Research Council; Faculté des Sciences de la Vie, École Polytechnique Fédérale de Lausanne; Scottish Funding Council; Bundesministerium für Forschung und Technologie; School of Medicine, Boston University; European Commission; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Kidney Foundation of Canada; Fonds de Recherche du Québec - Santé; KfH-Stiftung Präventivmedizin; Universitätsspital Basel; Institut Necker-Enfants Malades; Novartis; Mach-Gaensslen Foundation of Canada; National Heart, Lung, and Blood Institute; Scottish Government Health and Social Care Directorate; Deutsche Forschungsgemeinschaft; Common Fund; Directorate for Biological Sciences; GlaxoSmithKline; Age UK; Ministarstvo znanosti i obrazovanja; National Science Foundation","keywords":"Tamm–Horsfall protein; Genetic variants; Locus (genetics); Kidney; Urinary system; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002776228,0.00122976,0.002274137,0.001861036,0.0008270406,0.00211539,0.001194939,0.001543508,0.003765807],"category_scores_gemma":[0.006042503,0.0008178315,0.007618755,0.003957896,0.000477981,0.0004630781,0.001137078,0.001439459,0.0003033801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003932463,"about_ca_system_score_gemma":0.0005876306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0061604,"about_ca_topic_score_gemma":0.007917372,"domain_scores_codex":[0.9967446,0.0009451082,0.0003324399,0.001367799,0.000293303,0.0003167387],"domain_scores_gemma":[0.9961169,0.001835142,0.0007145967,0.0007947005,0.0002472592,0.0002914395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002979712,0.00004482027,0.8837128,0.001004465,0.08746295,0.001891994,0.0001971009,0.001946794,0.008502716,0.0005787874,0.002017676,0.009660101],"study_design_scores_gemma":[0.0002614221,0.0002853531,0.9255655,0.0002188417,0.06232285,0.002035524,0.0001796796,0.003859988,0.001391811,0.001274342,0.002552759,0.00005189793],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9407225,0.04275378,0.007947435,0.001171502,0.0003813892,0.00004362849,0.004540117,0.000401315,0.002038328],"genre_scores_gemma":[0.995095,0.002218658,0.001080026,0.0001875361,0.00009426312,0.00002236116,0.0009533548,0.00005952475,0.0002893828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0061604,"threshold_uncertainty_score":0.01468229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03852517982796498,"score_gpt":0.2767881401723674,"score_spread":0.2382629603444024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}