{"id":"W4214770147","doi":"10.1002/cpt.2563","title":"PharmVar GeneFocus: <i>CYP3A5</i>","year":2022,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba","funders":"National Human Genome Research Institute; Erzincan Üniversitesi; National Institutes of Health; Vetenskapsrådet; Ontario Institute for Cancer Research; National Institute of General Medical Sciences; European Federation of Pharmaceutical Industries and Associations; Kungliga Tekniska Högskolan; Robert Bosch Stiftung; McGill University","keywords":"Pharmacogenomics; CYP3A5; Pharmacogenetics; Allele; Locus (genetics); Tacrolimus; Biology; Genetics; Computational biology; Medicine; Gene; Bioinformatics; Transplantation; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.005384026,0.002231205,0.005849444,0.0006700177,0.001252864,0.00008491896,0.003982298,0.003131535,0.04285545],"category_scores_gemma":[0.00007045574,0.002073228,0.003828211,0.00145094,0.00160052,0.0001678336,0.001833847,0.01224805,0.003405213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004693857,"about_ca_system_score_gemma":0.001919173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005250166,"about_ca_topic_score_gemma":0.000001412581,"domain_scores_codex":[0.9787068,0.01108003,0.004471429,0.002505953,0.0008022074,0.002433583],"domain_scores_gemma":[0.9879574,0.006762318,0.002267063,0.001276887,0.0002050071,0.001531345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002587704,0.002208431,0.00002527291,0.001741017,0.007960233,0.0004183638,0.0001111121,0.00003275433,0.0000623595,0.00004029994,0.1190675,0.8680739],"study_design_scores_gemma":[0.003835,0.0003689609,0.000002473082,0.0001438321,0.03573262,0.0002320945,0.00002499124,0.0002158421,0.00009538543,0.0001432338,0.957283,0.001922611],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007623836,0.9451571,0.00003578099,0.0009811616,0.04274268,0.003081552,0.001185192,0.0005960415,0.00614424],"genre_scores_gemma":[0.000007375356,0.886959,0.0002127159,0.09981807,0.00786298,0.001284977,0.0005393617,0.0005256988,0.002789825],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8661513,"threshold_uncertainty_score":0.9990427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6241503739757894,"score_gpt":0.6259530102670595,"score_spread":0.001802636291270088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}