{"id":"W4214770147","doi":"10.1002/cpt.2563","title":"PharmVar GeneFocus: <i>CYP3A5</i>","year":2022,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba","funders":"National Human Genome Research Institute; Erzincan Üniversitesi; National Institutes of Health; Vetenskapsrådet; Ontario Institute for Cancer Research; National Institute of General Medical Sciences; European Federation of Pharmaceutical Industries and Associations; Kungliga Tekniska Högskolan; Robert Bosch Stiftung; McGill University","keywords":"Pharmacogenomics; CYP3A5; Pharmacogenetics; Allele; Locus (genetics); Tacrolimus; Biology; Genetics; Computational biology; Medicine; Gene; Bioinformatics; Transplantation; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094191,0.0007217739,0.001304416,0.004168724,0.0002559969,0.001575801,0.001220866,0.0009658465,0.03105423],"category_scores_gemma":[0.002387543,0.0002157605,0.0008632689,0.006543374,0.0003673611,0.001343508,0.00109402,0.001261583,0.02476507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005964738,"about_ca_system_score_gemma":0.002470163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002298648,"about_ca_topic_score_gemma":0.002756483,"domain_scores_codex":[0.9994488,0.0001055232,0.0001048422,0.00007591442,0.0002118152,0.00005306958],"domain_scores_gemma":[0.9988233,0.0004442449,0.0002399048,0.00006794721,0.0003285714,0.0000958765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001208079,0.000037842,0.0004477402,0.01327898,0.00009020314,0.0001829184,0.0000901892,0.0001642825,0.002588089,0.005577997,0.1988713,0.7785496],"study_design_scores_gemma":[0.000009225324,0.00001348916,0.0005359068,0.00120961,0.00004430128,0.0003141853,0.00001097693,0.00002328355,0.0004080542,0.0005096234,0.9969141,0.000007313327],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002735178,0.8195942,0.01030944,0.00922371,0.003031154,0.0004467657,0.0468892,0.003184871,0.1045854],"genre_scores_gemma":[0.008993674,0.8586643,0.01732198,0.00614539,0.001392142,0.0003733899,0.07536711,0.0007587269,0.03098326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03105423,"threshold_uncertainty_score":0.1038867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6241503739757894,"score_gpt":0.6259530102670595,"score_spread":0.001802636291270088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}