{"id":"W4214776966","doi":"10.1002/jha2.390","title":"Single cell proteogenomic sequencing identifies a relapse‐fated AML subclone carrying <i>FLT3</i>‐ITD with CN‐LOH at chr13q","year":2022,"lang":"en","type":"article","venue":"eJHaem","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Genome Canada; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society; Princess Margaret Cancer Foundation","keywords":"NPM1; Biology; Cancer research; Myeloid leukemia; Myeloid; Fms-Like Tyrosine Kinase 3; Flow cytometry; Molecular biology; Tyrosine kinase; Exon; Mutation; Gene; Karyotype; Genetics; Receptor; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007968159,0.0002389909,0.0002107341,0.0003299998,0.0001974774,0.0003038267,0.0001906778,0.0005527599,0.0007805928],"category_scores_gemma":[0.0001996109,0.00009862852,0.000258709,0.0001223978,0.0001915425,0.00007317483,0.0002607894,0.000310721,0.0003588943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002399592,"about_ca_system_score_gemma":0.0001014242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363414,"about_ca_topic_score_gemma":0.001931904,"domain_scores_codex":[0.9998957,0.000008014393,0.000007528122,0.000032269,0.00002870585,0.00002781677],"domain_scores_gemma":[0.9998375,0.00004608988,0.00002281036,0.00001825826,0.00001866016,0.00005661167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001776061,0.00007083517,0.006747209,0.00001521049,0.000009880578,0.008631524,0.0001844312,0.0003255179,0.9799777,0.0001260003,0.0001367583,0.003597412],"study_design_scores_gemma":[0.00005104056,0.001590462,0.2703165,0.00002062685,0.0001093577,0.08315311,0.0006111037,0.01702812,0.6204139,0.0003801301,0.006282002,0.00004372289],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983357,0.00004134465,0.0007126743,0.00007500699,0.000006855039,0.00002221435,0.0002381052,0.00005431837,0.0005137496],"genre_scores_gemma":[0.9969831,0.0000432372,0.001536133,0.00006829877,0.000005256905,0.00001083364,0.0004507267,0.00002746694,0.0008749857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001363414,"threshold_uncertainty_score":0.002710938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740536720955739,"score_gpt":0.2486875823234821,"score_spread":0.2212822151139247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}