{"id":"W4214776966","doi":"10.1002/jha2.390","title":"Single cell proteogenomic sequencing identifies a relapse‐fated AML subclone carrying <i>FLT3</i>‐ITD with CN‐LOH at chr13q","year":2022,"lang":"en","type":"article","venue":"eJHaem","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Genome Canada; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society; Princess Margaret Cancer Foundation","keywords":"NPM1; Biology; Cancer research; Myeloid leukemia; Myeloid; Fms-Like Tyrosine Kinase 3; Flow cytometry; Molecular biology; Tyrosine kinase; Exon; Mutation; Gene; Karyotype; Genetics; Receptor; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007512855,0.0003722981,0.0005772724,0.000346341,0.000888505,0.00007697741,0.0004033621,0.0001096086,0.00122171],"category_scores_gemma":[0.0001056226,0.0003377253,0.0001493633,0.0009127809,0.0002137017,0.0001786831,0.0007614002,0.001109696,0.00029888],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005633657,"about_ca_system_score_gemma":0.001006419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041164,"about_ca_topic_score_gemma":0.0001788126,"domain_scores_codex":[0.996374,0.0002438207,0.0004856214,0.0008115268,0.00112903,0.0009560062],"domain_scores_gemma":[0.99827,0.0001219721,0.0002224506,0.0008765623,0.0001838412,0.0003251204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001052504,0.0001420615,0.004294598,0.0002717482,0.0001374694,0.002523337,0.003980034,0.000377002,0.9794031,0.0000132927,0.007400279,0.0004045166],"study_design_scores_gemma":[0.007224142,0.002020557,0.001640511,0.0002146099,0.0002710678,0.002607672,0.006019839,0.001246775,0.9476942,0.00004670645,0.03019568,0.0008182662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878346,0.001066096,0.00005535221,0.0010518,0.0002261303,0.001704184,0.00004577977,0.0003135168,0.00770248],"genre_scores_gemma":[0.9682866,0.00003128768,0.001177402,0.00041336,0.0002461988,0.0004004736,0.0001927012,0.0001635806,0.02908842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03170899,"threshold_uncertainty_score":0.9999075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740536720955739,"score_gpt":0.2486875823234821,"score_spread":0.2212822151139247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}