{"id":"W4214777037","doi":"10.3390/cells11050821","title":"miRNA-Dependent Regulation of AKT1 Phosphorylation","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; J.P. Bickell Foundation","keywords":"Phosphorylation; AKT1; Protein kinase B; Cell biology; PI3K/AKT/mTOR pathway; Cancer research; AKT2; Biology; Signal transduction; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357429,0.0002827837,0.0002038623,0.0001883928,0.0001832399,0.0003516191,0.0001412366,0.0001648215,0.001435171],"category_scores_gemma":[0.0001458225,0.0001726366,0.0003019713,0.0001652187,0.0002087017,0.0002199001,0.0002430117,0.0005205736,0.000628858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925946,"about_ca_system_score_gemma":0.0002868439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112119,"about_ca_topic_score_gemma":0.0004083136,"domain_scores_codex":[0.9998369,0.00001914669,0.00002290805,0.0000499174,0.00004177905,0.00002923721],"domain_scores_gemma":[0.9999297,0.00001162443,0.00002300814,0.0000084792,0.00001213488,0.00001506219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001896712,0.00003171197,0.0001977182,0.00004922741,0.000007511981,0.00003304048,0.00001722728,0.0000568092,0.997552,0.0002414807,0.0001087336,0.001514913],"study_design_scores_gemma":[0.00001286571,0.00008856007,0.002612232,0.000002630583,0.000009980744,0.00009721219,0.000009382974,0.000653183,0.9938295,0.00007508402,0.002605546,0.00000379305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869627,0.003026542,0.003928158,0.0001593359,0.0001196003,0.00005872518,0.001292358,0.0001998943,0.004252645],"genre_scores_gemma":[0.9900857,0.001377168,0.003480134,0.00007848948,0.00001714536,0.00007529429,0.001188401,0.00004300733,0.003654645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435171,"threshold_uncertainty_score":0.004801095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007657351869790286,"score_gpt":0.2237191328778031,"score_spread":0.2160617810080128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}