{"id":"W4214777037","doi":"10.3390/cells11050821","title":"miRNA-Dependent Regulation of AKT1 Phosphorylation","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; J.P. Bickell Foundation","keywords":"Phosphorylation; AKT1; Protein kinase B; Cell biology; PI3K/AKT/mTOR pathway; Cancer research; AKT2; Biology; Signal transduction; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603363,0.00006259098,0.0000673487,0.00002349398,0.00005859445,0.000004404766,0.0001203591,0.00004302033,0.0004629955],"category_scores_gemma":[0.0000088645,0.00007204073,0.00004868483,0.00006014736,0.00002321988,0.000001520047,0.00008960421,0.00005384111,0.000007855949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003497387,"about_ca_system_score_gemma":0.00004792294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001709444,"about_ca_topic_score_gemma":0.000002701684,"domain_scores_codex":[0.9993759,0.00004294712,0.0001407343,0.0001769089,0.0001683158,0.00009523133],"domain_scores_gemma":[0.999598,0.000006553997,0.0001024736,0.0002276172,0.00004209248,0.00002332385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005055254,0.00002934048,0.0004400878,0.000007933017,0.00001422029,4.697447e-7,0.00004536361,0.004883918,0.9887096,0.00003839899,0.004288846,0.001491257],"study_design_scores_gemma":[0.0002369361,0.0001391685,0.001241457,0.0000025255,0.000008904905,0.000002100776,0.00003389321,0.0001473426,0.954906,0.0001152066,0.04308655,0.00007990717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951012,0.0008609416,0.001109982,0.00004144941,0.0005193785,0.000127447,0.00003207915,0.000008774779,0.002198752],"genre_scores_gemma":[0.9966877,0.00002280584,0.0002780601,0.00007844526,0.0001002504,0.00001978754,0.00009092588,0.00001356273,0.00270853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03879771,"threshold_uncertainty_score":0.5069476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007657351869790286,"score_gpt":0.2237191328778031,"score_spread":0.2160617810080128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}