{"id":"W4214826497","doi":"10.1139/facets-2021-0157","title":"Peptidases: promising antifungal targets of the human fungal pathogen, <i>Cryptococcus neoformans</i>","year":2022,"lang":"en","type":"article","venue":"FACETS","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; University of Guelph","keywords":"Cryptococcus neoformans; Virulence; Biology; Cryptococcosis; Microbiology; Pathogen; Human pathogen; Cryptococcus gattii; Virulence factor; Fungus; Cryptococcus; Fungal pathogen; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711451,0.000537322,0.0003051618,0.0004414831,0.00013558,0.0005257684,0.0001853781,0.0004274486,0.002337717],"category_scores_gemma":[0.0001690654,0.00008052636,0.0002803261,0.0004367489,0.0001391493,0.0004207888,0.0002037249,0.0004491118,0.001142606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691672,"about_ca_system_score_gemma":0.0004119671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007563828,"about_ca_topic_score_gemma":0.001190891,"domain_scores_codex":[0.9999331,0.00001040636,0.000006572737,0.0000102918,0.00002364508,0.00001596389],"domain_scores_gemma":[0.9999462,0.000006741057,0.00001810143,0.000002137254,0.00001310472,0.00001365768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009521998,0.0001600016,0.002176513,0.004833904,0.00009915413,0.001406616,0.0001032106,0.001173912,0.5332789,0.00378485,0.01161867,0.4404121],"study_design_scores_gemma":[0.0001232494,0.001563934,0.0121736,0.000986187,0.0001958642,0.006878661,0.0001792994,0.0008751852,0.2997953,0.001530384,0.6756504,0.00004783681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.08267637,0.8825128,0.006355106,0.002616528,0.0006622343,0.000166249,0.001909704,0.0002074179,0.02289363],"genre_scores_gemma":[0.351225,0.6105422,0.01610843,0.002277671,0.0005222415,0.00009847511,0.004097665,0.0000413764,0.01508694],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002337717,"threshold_uncertainty_score":0.007820487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01639798202838686,"score_gpt":0.2641428850708036,"score_spread":0.2477449030424167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}