{"id":"W4214843492","doi":"10.1111/bjh.18116","title":"<scp>KIT D816V</scp> is dimerization‐independent and activates downstream pathways frequently perturbed in mastocytosis","year":2022,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Sunnybrook Hospital; Sunnybrook Health Science Centre; University of Ottawa; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Receptor tyrosine kinase; Tyrosine kinase; Signal transduction; Stem cell factor; Proto-Oncogene Proteins c-kit; Systemic mastocytosis; Mutant; Biology; Proto-oncogene tyrosine-protein kinase Src; Cancer research; MAPK/ERK pathway; Cell biology; Chemistry; Haematopoiesis; Biochemistry; Mast cell; Immunology; Stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003327397,0.0001726943,0.0006502141,0.0002855362,0.0003156948,0.00003413715,0.0002854746,0.000178445,0.001781877],"category_scores_gemma":[0.0001459455,0.0001962926,0.0001167139,0.0001785296,0.0002035724,0.0001304766,0.0002019439,0.0007711815,0.00001914967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006875682,"about_ca_system_score_gemma":0.0001069358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002499518,"about_ca_topic_score_gemma":0.0001001837,"domain_scores_codex":[0.9982239,0.0003656524,0.0006615859,0.000269296,0.00009389166,0.0003856996],"domain_scores_gemma":[0.9990086,0.0002457571,0.0004729336,0.0001302167,0.00008976524,0.00005271543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.0004995457,0.002887317,0.05460503,0.0003208813,0.00133855,0.04262065,0.01169396,0.0001596435,0.7469556,0.004672314,0.08934503,0.04490152],"study_design_scores_gemma":[0.01065997,0.001678714,0.02987546,0.0002656718,0.0002236774,0.6415182,0.009000778,0.00003204813,0.0778567,0.001932265,0.2265117,0.0004447367],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98269,0.01501251,0.00005542484,0.0003492824,0.0006411216,0.0001515997,0.000115119,0.00001518523,0.0009697576],"genre_scores_gemma":[0.9971454,0.001101926,0.000105253,0.0004025606,0.00002559216,0.00001930529,0.0000494187,0.00002250907,0.001128035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6690989,"threshold_uncertainty_score":0.9991306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008797379183238982,"score_gpt":0.1946088982529008,"score_spread":0.1858115190696618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}