{"id":"W4214843492","doi":"10.1111/bjh.18116","title":"<scp>KIT D816V</scp> is dimerization‐independent and activates downstream pathways frequently perturbed in mastocytosis","year":2022,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Sunnybrook Hospital; Sunnybrook Health Science Centre; University of Ottawa; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Receptor tyrosine kinase; Tyrosine kinase; Signal transduction; Stem cell factor; Proto-Oncogene Proteins c-kit; Systemic mastocytosis; Mutant; Biology; Proto-oncogene tyrosine-protein kinase Src; Cancer research; MAPK/ERK pathway; Cell biology; Chemistry; Haematopoiesis; Biochemistry; Mast cell; Immunology; Stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007964346,0.0002106449,0.0001790527,0.0001100449,0.0001697986,0.0002468042,0.0001422327,0.0003871418,0.001971572],"category_scores_gemma":[0.0001010866,0.00008495779,0.0002258201,0.0001269871,0.0002218215,0.0001250322,0.0001571191,0.0004586805,0.0006831849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212402,"about_ca_system_score_gemma":0.0001105108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003765237,"about_ca_topic_score_gemma":0.0004040599,"domain_scores_codex":[0.9998123,0.00002978755,0.00001635238,0.0000370553,0.00006341649,0.00004113599],"domain_scores_gemma":[0.9999331,0.00001166919,0.00002232635,0.00001019436,0.000005577906,0.00001715375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005500035,0.00001130196,0.0001870533,0.00001462751,0.000003242739,0.0002021204,0.000004447907,0.0000467344,0.9987242,0.0001008807,0.000075697,0.0005747569],"study_design_scores_gemma":[0.0000182866,0.0002419749,0.01239634,0.000006685697,0.00001078788,0.003483717,0.0000448127,0.0009076287,0.9784581,0.0001830723,0.004240979,0.000007600492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955946,0.0005476626,0.001259986,0.0001306935,0.00002517547,0.00001537773,0.0006636217,0.00005019759,0.001712674],"genre_scores_gemma":[0.9972621,0.0002107568,0.000514738,0.00006804881,0.000005473251,0.00001559452,0.0006210986,0.00001545199,0.001286838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001971572,"threshold_uncertainty_score":0.006595552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008797379183238982,"score_gpt":0.1946088982529008,"score_spread":0.1858115190696618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}