{"id":"W4214844963","doi":"10.3389/fcell.2022.769853","title":"Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused by Lis1 (Pafah1b1) Mutation Produce a Non-drastic Functional Phenotype","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agencia Estatal de Investigación; Canadian Institutes of Health Research; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Azrieli Foundation; National Natural Science Foundation of China; Israel Science Foundation; Generalitat Valenciana; Ministerio de Ciencia e Innovación; International Development Research Centre","keywords":"Lissencephaly; Neuroscience; Parvalbumin; Calretinin; GABAergic; Biology; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Cortex (anatomy); Cerebral cortex; Phenotype; Postsynaptic potential; Genetics; Gene; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007752924,0.0007313908,0.000240475,0.0007024478,0.0001406757,0.0001625623,0.0001797572,0.0003192611,0.001306273],"category_scores_gemma":[0.0001539332,0.0001843933,0.0002197475,0.0001650857,0.000338614,0.00009883187,0.0002547831,0.000380542,0.0004595919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508865,"about_ca_system_score_gemma":0.0001847062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005976389,"about_ca_topic_score_gemma":0.0008690369,"domain_scores_codex":[0.999896,0.000008401082,0.00001360466,0.00002789972,0.00003629723,0.0000176552],"domain_scores_gemma":[0.9998257,0.00002126998,0.00008447016,0.00001247949,0.00001210571,0.00004393201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005342522,0.00001702915,0.0005583963,0.00003462734,0.000007018277,0.0005659217,0.00001681037,0.00005583239,0.9974002,0.00006132474,0.00002606329,0.001203442],"study_design_scores_gemma":[0.00004062623,0.0003982877,0.06432649,0.00002038586,0.00006337499,0.007066763,0.00006549569,0.0009534163,0.9242826,0.0002192155,0.002543666,0.00001969886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961501,0.0004666257,0.002006401,0.00004020382,0.00001367365,0.00001961348,0.0003709354,0.000159511,0.0007729012],"genre_scores_gemma":[0.9945896,0.0006171292,0.001988587,0.0000258276,0.000009544246,0.00004004365,0.0006813272,0.00003978078,0.002008196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306273,"threshold_uncertainty_score":0.004369915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004860986955450629,"score_gpt":0.184490483819142,"score_spread":0.1796294968636914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}