{"id":"W4214857503","doi":"10.1101/2022.02.28.482398","title":"Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Health and Medical Research Council; Queensland Brain Institute; Medical Research Council; Helsinki Institute of Life Science, Helsingin Yliopisto; Allergan; University of Queensland; Helsingin Yliopisto","keywords":"Endocytic cycle; Synaptotagmin 1; Synaptic vesicle; Neurotoxicity; Chemistry; Biology; Cell biology; Receptor; Membrane; Biochemistry; Vesicle; Endocytosis; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384617,0.0002437296,0.0002102015,0.000183928,0.000301282,0.000270003,0.0001736959,0.0004146172,0.002294189],"category_scores_gemma":[0.0001260414,0.0001146326,0.0002164757,0.0000970568,0.0002377567,0.0002228647,0.0003943844,0.0003591967,0.0005343472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000514149,"about_ca_system_score_gemma":0.0002680146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008610794,"about_ca_topic_score_gemma":0.0009978603,"domain_scores_codex":[0.9999295,0.000008261952,0.000004368878,0.00001489716,0.00001815503,0.00002476226],"domain_scores_gemma":[0.9999424,0.00001061851,0.00001092913,0.000006047522,0.000009299279,0.00002064816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056544,0.0000121396,0.0003885886,0.00003681639,0.000004468534,0.00021583,0.00001717261,0.00005261176,0.9981847,0.0003204237,0.0001398644,0.0005216909],"study_design_scores_gemma":[0.00003253141,0.0001735817,0.0224337,0.00001498123,0.00001629496,0.001199979,0.0001298857,0.002660555,0.9694411,0.0006715111,0.003217948,0.00000789362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949943,0.001159242,0.001019486,0.0001874524,0.00004439055,0.00001273484,0.0001185931,0.00003505786,0.002428767],"genre_scores_gemma":[0.9967266,0.00035075,0.0004082134,0.00006817429,0.00001124799,0.000007959789,0.0001141918,0.00000776762,0.002304913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294189,"threshold_uncertainty_score":0.007674813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804386958115224,"score_gpt":0.2397064780281581,"score_spread":0.2216626084470059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}